Cells grow more naturally in “spaghetti”
The usual way of cultivating cells is to use a flat laboratory dish of glass. However, inside a human body, the cells do not grow on a flat surface, but rather in three dimensions. This has lead researchers at Lund University in Sweden to develop a porous “spaghetti” of tissue-friendly polymers with cavities in which the cells can develop in a more natural way.
The Lund researchers have achieved good results with their three-dimensional fibre structures. If the new technique delivers what it promises, electrospinning will be able to provide new opportunities for both research and industry. With more natural cell cultures on which to conduct research, a number of biomedical research issues can be addressed in new ways.
The publications can be found here:
Three-dimensional functional human neuronal networks in uncompressed low-density electrospun fiber scaffolds in Nanomedicine, DOI: 10.1016/j.nano.2016.12.023
Tailor-Made Electrospun Culture Scaffolds Control Human Neural Progenitor Cell Behavior— Studies on Cellular Migration and Phenotypic Differentiation in Journals of Biomaterials and Nano Biotechnology, DOI: 10.4236/jbnb.2017.81001
Exploration of physical and chemical cues on retinal cell fate in Molecular and Cellular Neuroscience, DOI: 10.1016/j.mcn.2016.07.006