PhD defense - Stefan Holm

Friday 16 March 2018 14:15 - 16:00
Published 2018-03-05 10:19 by Jonas Tegenfeldt

Title: Microfluidic Cell and Particle Sorting using Deterministic Lateral Displacement
Link to thesis.
Opponent: Prof Brian Kirby, Cornell University, Ithaca, NY, USA
Abbreviated abstract:
Microfluidics is a field which has the potential to revolutionize medical diagnostics. The ability to sort and analyse cells
by the use of portable handheld devices has the potential to enable sensitive devices for point-of-care diagnostics. This could play a major role in diagnosis of a wide range of diseases which are prevalent in remote areas in developing countries where a majority of the people live without access to modern health care.
One focus of this thesis is the development of such a tool for diagnosis of human African trypanosomiasis, a deadly disease which requires accurate and rapid diagnosis in order to start treatment at an early stage for better chances of survival. The way the disease is normally diagnosed is by microscopic examination of blood smears in order to see if the blood parasite which causes
HAT is present in the patient or not. This is a tremendously difficult task as in a single drop of blood there can be 500 mil
lion red blood cells (RBC) while at the same time the number of parasites can be less than 10. The vast majority of background cells makes finding the parasite as difficult as finding a needle in a haystack. To help in diagnosis we present a way by which we separate out the blood parasites, if present, from the blood so they can be easily detected.