Seminar by Damiano Verardo's opponent Christian Eggeling

Friday 16 November 2018 09:00 - 10:00
k-space
Published 2018-11-03 12:22 by Heiner Linke

Seminar by Christian Eggeling, Oxford University
https://www.imm.ox.ac.uk/research/units-and-centres/mrc-human-immunology-unit/research-groups/eggeling-group

Challenges and potentials of physics in biomedical research – a super-resolution microscopy

Understanding the complex interactions of molecular processes underlying the efficient functioning of the human body is one of the main objectives of biomedical research. Scientifically, it is important that the applied observation methods do not influence the biological system during observation. A suitable tool that can cover all of this is optical far-field fluorescence microscopy. Yet, biomedical applications often demand coverage of a large range of spatial and temporal scales, and/or long acquisition times, which can so far not all be covered by a single microscope and puts some challenges on the physics of microscopes and microscope infrastructure. We outline these challenges but also give new insights into possible solutions and the potentials of these advanced microscopy techniques, e.g. for solving long-standing questions such as of lipid membrane rafts.

Key words: Super-resolution microscopy, STED microscopy, STED-FCS, T-cell activation, plasma membrane organization, lipid rafts


Contact: Heiner Linke