Portait of Anders Gudmundsson. Photo: Kennet Ruona

Anders Gudmundsson

Professor

Portait of Anders Gudmundsson. Photo: Kennet Ruona

Inhalation and Dermal Uptake of Particle and Gas-phase Phthalates - A Human Exposure Study

Author

  • Christina Andersen
  • Annette Krais
  • Axel C Eriksson
  • Jonas Jakobsson
  • Jakob Löndahl
  • Jörn Nielsen
  • Christian H Lindh
  • Joakim Pagels
  • Anders Gudmundsson
  • Aneta Wierzbicka

Summary, in English

Phthalates are ubiquitous in indoor environments, which raises concern about their endocrine disrupting properties. However, studies of human uptake from airborne exposure are limited. We studied the inhalation uptake and dermal uptake by air-to-skin transfer with clean clothing as a barrier of two deuterium-labelled airborne phthalates: particle-phase D4-DEHP (di-(2-ethylhexyl)phthalate) and gas-phase D4-DEP (diethyl phthalate). Sixteen participants, wearing trousers and long-sleeved shirts, were under controlled conditions exposed to airborne phthalates in four exposure scenarios: dermal uptake alone, and combined inhalation+dermal uptake of both phthalates. The results showed an average uptake of D4-DEHP by inhalation of 0.0014±0.00088 (µg kg-1 bw)/(µg m-3)/h. No dermal uptake of D4-DEHP was observed during the 3 hour exposure with clean clothing. The deposited dose of D4-DEHP accounted for 26% of the total inhaled D4-DEHP mass. For D4-DEP, the average uptake by inhalation+dermal was 0.0067±0.0045 and 0.00073±0.00051 (µg kg-1 bw)/(µg m-3)/h for dermal uptake. Urinary excretion factors of metabolites after inhalation were estimated to 0.69 for D4-DEHP and 0.50 for D4-DEP. Under the described settings, the main uptake of both phthalates was through inhalation. The results demonstrate the differences in uptake of gas and particles, and highlights the importance of considering the deposited dose in particle uptake studies.

Department/s

  • Ergonomics and Aerosol Technology
  • NanoLund
  • Division of Occupational and Environmental Medicine, Lund University
  • Applied Mass Spectrometry in Environmental Medicine

Publishing year

2018-09-28

Language

English

Pages

12792-12800

Publication/Series

Environmental Science & Technology

Volume

52

Issue

21

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Environmental Health and Occupational Health

Status

Published

Research group

  • Applied Mass Spectrometry in Environmental Medicine

ISBN/ISSN/Other

  • ISSN: 1520-5851