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New imaging method sheds light on Alzheimer’s disease

Photo of Oxana Klementieva.

Oxana Klementieva and her colleagues in Lund and at Synchrotron SOLEIL in France have used a new method, optical photothermal spectroscopy (O-PTIR) to study protein structures in neurons from mice affected by early stage Alzheimer’s disease. 

“We saw that the structure of the protein changes in different ways depending on where in the nerve cell it is. So far, there have been no methods that can produce these types of images, giving us insight into what the first molecular changes in neurons actually look like in Alzheimer's disease”, says Oxana Klementieva.

Their work has been published in the journal Advanced Science, and featured on the cover page.