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SUMMARY:Minisymposium on single-molecule visualization\, design and enginee
 ring
DESCRIPTION:Contact: heiner.linke@fysik.lu.se\n\nMinisymposium\, 3 Septembe
 r 2026\, Lundmarksalen14.00 &nbsp\;Lisanne Spenkelink\, University of Woll
 ongong\, AustraliaSingle-molecule visualisation of dynamics in complex bio
 logical systems.My lab develops and applies single-molecule fluorescence m
 ethods to investigate biological processes and to build highly sensitive b
 iosensors. In this seminar\, I will give an overview of our recent work\, 
 spanning DNA replication and genome maintenance\, protein evolution\, and 
 single-molecule approaches for biomarker detection.14.45 &nbsp\;Jonathan B
 ath\, Oxford University\, UKMolecular machines for sequence-controlled pol
 ymer synthesis.I will describe molecular machines built from DNA that are 
 designed to catalyse stepwise synthesis of sequence-controlled polymers. I
 nitial designs use a molecular motor to visit monomers laid out linear tra
 cks in a controlled sequence with coupling chemistry catalysed by proximit
 y. Later designs incorporate mechanisms to coordinate stepwise movement wi
 th the coupling chemistry. Progress has been slow because the coupling che
 mistry requires a careful balance between reactivity and inactivation by h
 ydrolysis. I will end by describing a strategy for combinatorial non-coval
 ent assembly.15.15 &nbsp\;Timothy Jenkins\, DTU\, DenmarkFrom Months to Mi
 nutes: How Generative AI is Rewriting the Rules of Protein DiscoveryGenera
 tive AI is shifting biology from analysing natural proteins to designing e
 ntirely new ones with bespoke functions. Drawing on recent case studies\, 
 including protein binders for snakebite therapeutics and engineered binder
 s targeting peptide–MHC complexes for cancer immunotherapy\, I will show
  how this approach can dramatically accelerate discovery. As these tools m
 ature\, they signal a paradigm shift for biotechnology with clear implicat
 ions across medicine and beyond.16.00 End\n\nMore information about the ev
 ent: https://www.nano.lu.se/calendar/minisymposium-single-molecule-visuali
 zation-design-and-engineering
DTSTART;TZID=GMT:20260903T120000
DTEND;TZID=GMT:20260903T140000
LOCATION:Lundmarksalen\, Astronomihuset
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