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Portrait photo of Gerda Rentschler

Gerda Rentschler

Project Coordinator

Portrait photo of Gerda Rentschler

Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries

Author

  • Gerda Rentschler
  • Ilia Rodushkin
  • Milena Cerna
  • Chunying Chen
  • Florencia Harari
  • Raúl Harari
  • Milena Horvat
  • Frantiska Hruba
  • Lucie Kasparova
  • Kvetoslava Koppova
  • Andrea Krskova
  • Mladen Krsnik
  • Jawhar Laamech
  • Yu Feng Li
  • Lina Löfmark
  • Thomas Lundh
  • Nils Göran Lundström
  • Badiaa Lyoussi
  • Darja Mazej
  • Josko Osredkar
  • Krystyna Pawlas
  • Natalia Pawlas
  • Adam Prokopowicz
  • Staffan Skerfving
  • Janja Snoj Tratnik
  • Vera Spevackova
  • Zdravko Spiric
  • Anneli Sundkvist
  • Ulf Strömberg
  • Drazenka Vadla
  • Katerina Wranova
  • Soumia Zizi
  • Ingvar A. Bergdahl

Summary, in English

Background: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. Objectives: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. Methods: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. Results: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6). ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60. ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P = 0.05; all other elements P. <. 0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations. Conclusions: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.

Department/s

  • Division of Occupational and Environmental Medicine, Lund University
  • Genetic Occupational and Environmental Medicine
  • Work-related musculoskeletal disorders

Publishing year

2018

Language

English

Pages

223-230

Publication/Series

International Journal of Hygiene and Environmental Health

Volume

221

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Environmental Health and Occupational Health

Keywords

  • Biomarkers
  • Biomonitoring
  • Catalytic converters
  • Cis-platinum
  • High-resolution ICP-MS
  • Human
  • Metals
  • Traffic
  • Women

Status

Published

Research group

  • Genetic Occupational and Environmental Medicine
  • Work-related musculoskeletal disorders

ISBN/ISSN/Other

  • ISSN: 1438-4639