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Portrait photo of Gerda Rentschler

Gerda Rentschler

Project Coordinator

Portrait photo of Gerda Rentschler

Long-term lead elimination from plasma and whole blood after poisoning.

Author

  • Gerda Rentschler
  • Karin Broberg Palmgren
  • Thomas Lundh
  • Staffan Skerfving

Summary, in English

OBJECTIVE:



Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.

METHODS:



A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.

RESULTS:



P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.

CONCLUSION:



P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.

Department/s

  • Division of Occupational and Environmental Medicine, Lund University

Publishing year

2012

Language

English

Pages

311-316

Publication/Series

International Archives of Occupational and Environmental Health

Volume

85

Document type

Journal article

Publisher

Springer

Topic

  • Environmental Health and Occupational Health

Status

Published

ISBN/ISSN/Other

  • ISSN: 1432-1246