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Portrait of Heiner Linke; Photo: Kennet Ruona

Heiner Linke

Professor, Deputy dean at Faculty of Engineering, LTH

Portrait of Heiner Linke; Photo: Kennet Ruona

Mechanochemical model for myosin V

Author

  • Erin M. Craig
  • Heiner Linke

Summary, in English

A rigorous numerical test of a hypothetical mechanism of a molecular motor should model explicitly the diffusive motion of the motor's degrees of freedom as well as the transition rates between the motor's chemical states. We present such a Brownian dynamics, mechanochemcial model of the coarse-grain structure of the dimeric, linear motor myosin V. Compared with run-length data, our model provides strong support for a proposed strain-controlled gating mechanism that enhances processivity. We demonstrate that the diffusion rate of a detached motor head during motor stepping is self-consistent with known kinetic rate constants and can explain the motor's key performance features, such as speed and stall force. We present illustrative and realistic animations of motor stepping in the presence of thermal noise. The quantitative success and illustrative power of this type of model suggest that it will be useful in testing our understanding of a range of biological and synthetic motors.

Department/s

  • Solid State Physics

Publishing year

2009

Language

English

Pages

18261-18266

Publication/Series

Proceedings of the National Academy of Sciences

Volume

106

Issue

43

Document type

Journal article

Publisher

National Acad Sciences

Topic

  • Condensed Matter Physics

Keywords

  • Brownian dynamics
  • molecular motor
  • strain-dependent gating

Status

Published

ISBN/ISSN/Other

  • ISSN: 1091-6490