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Portrait of Heiner Linke; Photo: Kennet Ruona

Heiner Linke

Professor, Deputy dean at Faculty of Engineering, LTH

Portrait of Heiner Linke; Photo: Kennet Ruona

Nano-structuring for molecular motor control

Author

  • Mercy Lard
  • L. Ten Siethoff
  • S. Kumar
  • M. Persson
  • G. te Kronnie
  • A. Månsson
  • H. Linke

Summary, in English

The interaction of self-propelled biological molecular-motors and cytoskeletal filaments holds relevance for a variety of applications such as biosensing, drug screening, diagnostics and biocomputation. The use of these systems for lab-on-a-chip biotechnology applications shows potential for replacement of microfluidic flow by active, molecular-motor driven transport of filaments. The ability to control, confine and detect motile objects in such a system is possible by development of nanostructured surfaces for on-chip applications and fundamental studies of molecular-motors. Here we describe the localized detection (Lard et al., Sci Rep 3:1092, 2013) and fast transport of actin filaments by myosin molecular-motors (Lard et al., Biosens Biolectron 48(0):145–152, 2013), inserted within nanostructures, as a method for biocomputation and molecular concentration. These results include extensive myosin driven concentration of actin filaments on a miniaturized detector, of relevance for use of molecular-motors in a diagnostics platform. Also, we discuss the local enhancement of the fluorescence signal of filaments, relevant for use in a biocomputation device where tracking of potentially thousands of motile objects is of primary significance.

Department/s

  • NanoLund

Publishing year

2015

Language

English

Pages

459-459

Document type

Conference paper: abstract

Topic

  • Other Medical Engineering

Conference name

NATO Advanced Study Institute on Nano-Structures for Optics and Photonics: Optical Strategies for Enhancing Sensing, Imaging, Communication, and Energy Conversion

Conference date

2013-07-04 - 2013-07-19

Conference place

Erice, Italy

Status

Published