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Portrait of Heiner Linke; Photo: Kennet Ruona

Heiner Linke

Professor, Deputy dean (prorektor) at Faculty of Engineering, LTH

Portrait of Heiner Linke; Photo: Kennet Ruona

Ultrafast molecular motor driven nanoseparation and biosensing.


  • Mercy Lard
  • Lasse Ten Siethoff
  • Saroj Kumar
  • Malin Persson
  • Geertruy Te Kronnie
  • Heiner Linke
  • Alf Månsson

Summary, in English

Portable biosensor systems would benefit from reduced dependency on external power supplies as well as from further miniaturization and increased detection rate. Systems built around self-propelled biological molecular motors and cytoskeletal filaments hold significant promise in these regards as they are built from nanoscale components that enable nanoseparation independent of fluidic pumping. Previously reported microtubule-kinesin based devices are slow, however, compared to several existing biosensor systems. Here we demonstrate that this speed limitation can be overcome by using the faster actomyosin motor system. Moreover, due to lower flexural rigidity of the actin filaments, smaller features can be achieved compared to microtubule-based systems, enabling further miniaturization. Using a device designed through optimization by Monte Carlo simulations, we demonstrate extensive myosin driven enrichment of actin filaments on a detector area of less than 10μm(2), with a concentration half-time of approximately 40s. We also show accumulation of model analyte (streptavidin at nanomolar concentration in nanoliter effective volume) detecting increased fluorescence intensity within seconds after initiation of motor-driven transportation from capture regions. We discuss further optimizations of the system and incorporation into a complete biosensing workflow.


  • Solid State Physics
  • NanoLund: Center for Nanoscience

Publishing year







Biosensors & Bioelectronics



Document type

Journal article




  • Condensed Matter Physics



Research group

  • Nanometer structure consortium (nmC)


  • ISSN: 1873-4235