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Jakob Löndahl

Jakob Löndahl

Associate Professor / Senior Lecturer

Jakob Löndahl

Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests


  • Madeleine Petersson-Sjögren
  • Jonas Jakobsson
  • H. Laura Aaltonen
  • Hanna Nicklasson
  • Jenny Rissler
  • Gunnar Engström
  • Per Wollmer
  • Jakob Löndahl

Summary, in English

Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.


  • Ergonomics and Aerosol Technology
  • NanoLund: Center for Nanoscience
  • Nuclear physics
  • Radiology Diagnostics, Malmö
  • Cardiovascular Research - Epidemiology
  • EpiHealth: Epidemiology for Health

Publishing year







International Journal of Nanomedicine



Document type

Journal article


Dove Medical Press Ltd.


  • Medical Laboratory and Measurements Technologies


  • aerosol nanoparticles
  • airspace dimension assessment with nanoparticles
  • COPD diagnostics
  • distal airspaces
  • respiratory diagnostics with nanoparticles



Research group

  • Radiology Diagnostics, Malmö
  • Cardiovascular Research - Epidemiology


  • ISSN: 1176-9114