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Jakob Löndahl

Jakob Löndahl

Associate Professor / Senior Lecturer

Jakob Löndahl

A new method for measuring lung deposition efficiency of airborne nanoparticles in a single breath


  • Jonas K F Jakobsson
  • Johan Hedlund
  • John Kumlin
  • Per Wollmer
  • Jakob Löndahl

Summary, in English

Assessment of respiratory tract deposition of nanoparticles is a key link to understanding their health impacts. An instrument was developed to measure respiratory tract deposition of nanoparticles in a single breath. Monodisperse nanoparticles are generated, inhaled and sampled from a determined volumetric lung depth after a controlled residence time in the lung. The instrument was characterized for sensitivity to inter-subject variability, particle size (22, 50, 75 and 100 nm) and breath-holding time (3-20 s) in a group of seven healthy subjects. The measured particle recovery had an inter-subject variability 26-50 times larger than the measurement uncertainty and the results for various particle sizes and breath-holding times were in accordance with the theory for Brownian diffusion and values calculated from the Multiple-Path Particle Dosimetry model. The recovery was found to be determined by residence time and particle size, while respiratory flow-rate had minor importance in the studied range 1-10 L/s. The instrument will be used to investigate deposition of nanoparticles in patients with respiratory disease. The fast and precise measurement allows for both diagnostic applications, where the disease may be identified based on particle recovery, and for studies with controlled delivery of aerosol-based nanomedicine to specific regions of the lungs.


  • Ergonomics and Aerosol Technology
  • NanoLund: Center for Nanoscience
  • Clinical Physiology, Malmö
  • MERGE: ModElling the Regional and Global Earth system

Publishing year





Scientific Reports



Document type

Journal article


Nature Publishing Group


  • Respiratory Medicine and Allergy



Research group

  • Clinical Physiology, Malmö


  • ISSN: 2045-2322