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Jakob Löndahl

Jakob Löndahl

Associate Professor / Senior Lecturer

Jakob Löndahl

Inhalation and dermal uptake of particle and gas phase phthalates - A human chamber exposure study


  • Christina Andersen
  • Annette M. Krais
  • Axel C. Eriksson
  • Jonas Jakobsson
  • Jakob Löndahl
  • Christian H. Lindh
  • Joakim Pagels
  • Jörn Nielsen
  • Anders Gudmundsson
  • Aneta Wierzbicka

Summary, in English

We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the metabolites were found to be 0.73 for DEHP and 0.53 for DEP. This study also highlights the importance of taking into consideration the deposited dose of inhaled particles in studies of uptake of particles.


  • Ergonomics and Aerosol Technology
  • NanoLund: Center for Nanoscience
  • Division of Occupational and Environmental Medicine, Lund University

Publishing year





15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018

Document type

Conference paper


International Society of Indoor Air Quality and Climate (ISIAQ)


  • Environmental Health and Occupational Health


  • Dermal exposure
  • Inhalation
  • Lung deposition
  • Semi-volatile organic compounds (SVOCs)

Conference name

15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018

Conference date

2018-07-22 - 2018-07-27

Conference place

Philadelphia, United States




  • ISBN: 9781713826514