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Portrait of Joakim Pagels

Joakim Pagels

Senior Lecturer

Portrait of Joakim Pagels

Effects on heart rate variability by artificially generated indoor nano-sized particles in a chamber study


  • Inger Hagerman
  • Christina Isaxon
  • Anders Gudmundsson
  • Aneta Wierzbicka
  • Katrin Dierschke
  • Margareta Berglund
  • Joakim Pagels
  • Jörn Nielsen
  • Eva Assarsson
  • Ulla B Andersson
  • Yiyi Xu
  • Bo A Jönsson
  • Mats Bohgard

Summary, in English

Background: Airborne particles are associated with increased morbidity and mortality due to respiratory and cardiovascular diseases in polluted areas. There is a growing interest in nano-sized particles with diameter < 100 nm and their potential health effects. Heart rate variability (HRV) is a noninvasive method for cardiovascular risk prediction in high prevalent groups. Aim of study: The aim was to evaluate the impact of nano-sized indoor air particles on HRV for healthy and adult females. Methods: All exposures were performed as controlled chamber experiments with particle exposure from burning candles, terpene + ozone reactions or filtered air in a double-blind cross over design. Twenty-two healthy females were investigated during 10 min periods at different exposures and the reactivity in high frequency (HF) spectral band of HRV were computed. Results: Heart rate was unchanged from baseline values in all groups during all experimental settings. HF power of HRV tended to increase during exposure to particles from burning candle while particles from terpene + ozone reactions tended to decrease HF power. Conclusions: Exposure to nano-sized particles of burning candles or terpene + ozone reactions results in different patterns of heart rate variability, with signs of altered autonomic cardiovascular control. Practical implications: This study indicates that the HRV method may be used for information on physiological responses of exposure to different nano-sized particles and contribute to the understanding of mechanisms behind health effects of particle exposures. (C) 2014 The Authors. Published by Elsevier Ltd.


  • Ergonomics and Aerosol Technology
  • Division of Occupational and Environmental Medicine, Lund University
  • EpiHealth: Epidemiology for Health
  • NanoLund: Center for Nanoscience

Publishing year







Atmospheric Environment



Document type

Journal article




  • Meteorology and Atmospheric Sciences


  • Airborne particles
  • Nano particles
  • HRV
  • Cardiovascular
  • Autonomic
  • control




  • ISSN: 1352-2310