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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Combined density and size-based sorting in deterministic lateral displacement devices

Author

  • Stefan H. Holm
  • Jason P. Beech
  • Jonas O. Tegenfeldt

Summary, in English

We present a deterministic-lateral-displacement (DLD) device that extends the capabilities of this traditionally sizebased particle separation technique to also be sensitive to density. By the use of T-shaped posts instead of the normally cylindrical posts the particle trajectory through the device will be a function of its vertical position which in turn is determined by the buoyancy of the particles. The potential lies in fast sorting of complex biological samples together with diagnosis and treatment-monitoring of diseases affecting cell-density, eg. cancer, sickle-cell anemia and malaria. We demonstrate proof-of-principle of combined size-and-density-based sorting, specifically particles of identical size but different density.

Department/s

  • NanoLund
  • Solid State Physics

Publishing year

2013-01-01

Language

English

Pages

1224-1226

Publication/Series

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

Volume

2

Document type

Conference paper

Publisher

Chemical and Biological Microsystems Society

Topic

  • Other Basic Medicine

Keywords

  • Density
  • Deterministic lateral displacement
  • Fractionation

Conference name

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

Conference date

2013-10-27 - 2013-10-31

Conference place

Freiburg, Germany

Status

Published

ISBN/ISSN/Other

  • ISBN: 9781632666246