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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Micro- and nanofluidics for DNA analysis

Author

  • Jonas Tegenfeldt
  • Christelle Prinz
  • H Cao
  • RL Huang
  • RH Austin
  • SY Chou
  • EC Cox
  • JC Sturm

Summary, in English

Miniaturization to the micrometer and nanometer scale opens up the possibility to probe biology on a length scale where fundamental biological processes take place, such as the epigenetic and genetic control of single cells. To study single cells the necessary devices need to be integrated on a single chip; and, to access the relevant length scales, the devices need to be designed with feature sizes of a few nanometers up to several micrometers. We will give a few examples from the literature and from our own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules.

Department/s

  • Solid State Physics

Publishing year

2004

Language

English

Pages

1678-1692

Publication/Series

Analytical and Bioanalytical Chemistry

Volume

378

Issue

7

Document type

Journal article review

Publisher

Springer

Topic

  • Analytical Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 1618-2642