Your browser has javascript turned off or blocked. This will lead to some parts of our website to not work properly or at all. Turn on javascript for best performance.

The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Meandering nanochannels for imaging of ultra-long DNA molecules

Author

  • C. Freitag
  • J. Fritzsche
  • F. Persson
  • Kalim U. Mir
  • J. O. Tegenfeldt

Summary, in English

A new chip design for handling and studying chromosomal DNA is described. Folding the nanochannels enables us to image an entire yeast chromosome in a single field of view. Together with existing mapping techniques our new design opens up the possibility of directly analyzing entire chromosomes in a single field of view using fluorescence microscopy. This would enable, for example, identification of microorganisms on a single-cell basis and the complete physical mapping of the human genome, chromosome by chromosome.

Department/s

  • NanoLund
  • Solid State Physics

Publishing year

2011-12-01

Language

English

Pages

1758-1760

Publication/Series

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Volume

3

Document type

Conference paper

Topic

  • Medical Genetics
  • Cell Biology

Keywords

  • Chromosomal DNA
  • DNA analysis
  • Genomics
  • Nanofluidics

Conference name

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Conference date

2011-10-02 - 2011-10-06

Conference place

Seattle, WA, United States

Status

Published

ISBN/ISSN/Other

  • ISBN: 9781618395955