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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Gradient nanostructures for interfacing microfluidics and nanofluidics

Author

  • Han Cao
  • Jonas O. Tegenfeldt
  • Robert H. Austin
  • Stephen Y. Chou

Summary, in English

It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems.

Department/s

  • Solid State Physics

Publishing year

2002-10-14

Language

English

Pages

3058-3060

Publication/Series

Applied Physics Letters

Volume

81

Issue

16

Document type

Journal article

Publisher

American Institute of Physics (AIP)

Status

Published

ISBN/ISSN/Other

  • ISSN: 0003-6951