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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Bandpass Filtering of DNA Elastic Modes Using Confinement and Tension

Author

  • Jun Lin
  • Fredrik Persson
  • Joachim Fritzsche
  • Jonas Tegenfeldt
  • Omar A. Saleh

Summary, in English

During a variety of biological and technological processes, biopolymers are simultaneously subject to both confinement and external forces. Although significant efforts have gone into understanding the physics of polymers that are only confined, or only under tension, little work has been done to explore the effects of the interplay of force and confinement. Here, we study the combined effects of stretching and confinement on a polymer’s configurational freedom. We measure the elastic response of long double-stranded DNA molecules that are partially confined to thin, nanofabricated slits. We account for the data through a model in which the DNA’s short-wavelength transverse elastic modes are cut off by applied force and the DNA’s bending stiffness, whereas long-wavelength modes are cut off by confinement. Thus, we show that confinement and stretching combine to permit tunable bandpass filtering of the elastic modes of long polymers.

Department/s

  • Solid State Physics

Publishing year

2012

Language

English

Pages

96-100

Publication/Series

Biophysical Journal

Volume

102

Document type

Journal article

Publisher

Cell Press

Topic

  • Biophysics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1542-0086