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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Deformability-based sorting of red blood cells in deterministic lateral displacement devices

Author

  • Z. Zhang
  • K. Punyani
  • Ewan Henry
  • S. H. Holm
  • J. P. Beech
  • J. O. Tegenfeldt
  • Gerhard Gompper
  • Dmitry A. Fedosov

Summary, in English

Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much more complex dynamics within a DLD device, which not only brings additional complications but also provides new separation mechanisms (e.g., based on cell deformability). Further simulation results reveal that the post geometry which induces more cell deformation can be applied to effectively sort RBCs based on their rigidity.

Department/s

  • Solid State Physics
  • NanoLund

Publishing year

2016

Language

English

Pages

788-789

Publication/Series

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Document type

Conference paper

Publisher

Chemical and Biological Microsystems Society

Topic

  • Medical Laboratory and Measurements Technologies

Keywords

  • Bumper array
  • Mesoscopic simulation
  • Microfluidics
  • Post shape

Conference name

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Conference date

2016-10-09 - 2016-10-13

Conference place

Dublin, Ireland

Status

Published

ISBN/ISSN/Other

  • ISBN: 9780979806490