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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Directed self-organization of single DNA molecules in a nanoslit via embedded nanopit arrays

Author

  • Walter Reisner
  • Niels B. Larsen
  • Henrik Flyvbjerg
  • Jonas Tegenfeldt
  • Anders Kristensen

Summary, in English

We show that arrays of nanopit structures etched in a nanoslit can control the positioning and conformation of single DNA molecules in nanofluidic devices. By adjusting the spacing, organization and placement of the nanopits it is possible to immobilize DNA at predetermined regions of a device without additional chemical modification and achieve a high degree of control over local DNA conformation. DNA can be extended between two nanopits and in closely spaced arrays will self-assemble into "connect-the-dots" conformations consisting of locally pinned segments joined by fluctuating linkers. These results have broad implications for nanotechnology fields that require methods for the nanoscale positioning and manipulation of DNA.

Department/s

  • Solid State Physics

Publishing year

2009

Language

English

Pages

79-84

Publication/Series

Proceedings of the National Academy of Sciences

Volume

106

Issue

1

Document type

Journal article

Publisher

National Acad Sciences

Topic

  • Condensed Matter Physics

Keywords

  • DNA conformation
  • self-assembly
  • nanofluidics
  • polymer confinement

Status

Published

ISBN/ISSN/Other

  • ISSN: 1091-6490