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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Cell morphology and deformability in deterministic lateral displacement devices

Author

  • Jason P. Beech
  • Karl Adolfsson
  • Stefan H. Holm
  • Jonas O. Tegenfeldt

Summary, in English

Deterministic Lateral Displacement (DLD) devices have been used to separate particles based on size [1] and shape [2]. Here we show how DLD devices can also be used to separate particles based on their ability to deform under shear forces. Varying experimental conditions allows us to vary the relative contributions of size, morphology and deformability. The ability to distinguish between cells based on deformability with high resolution and throughput, in cheap and simple devices, could find highly interesting and relevant applications, for example in the detection of circulating tumor cells or malaria-infected blood cells.

Department/s

  • Solid State Physics
  • NanoLund

Publishing year

2011-12-01

Language

English

Pages

1355-1357

Publication/Series

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Volume

2

Document type

Conference paper

Topic

  • Other Medical Biotechnology

Keywords

  • Deformability
  • Deterministic lateral displacement
  • Morphology
  • Separation

Conference name

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Conference date

2011-10-02 - 2011-10-06

Conference place

Seattle, WA, United States

Status

Published

ISBN/ISSN/Other

  • ISBN: 9781618395955