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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Morphology-based sorting-blood cells and parasites

Author

  • Jason P. Beech
  • Stefan Holm
  • Michael P. Barrett
  • Jonas O. Tegenfeldt

Summary, in English

Morphology represents a hitherto unexploited source of specificity in microfluidic particle separation and may serve as the basis for label-free particle fractionation. There is a wealth of morphological changes in blood cells due to a wide range of clinical conditions, diseases, medication and other factors. Also, blood-borne parasites differ in morphology from blood cells. We present the use of Deterministic Lateral Displacement to create a chip-based, label-free diagnostic tool, capable of harvesting some of the wealth of information locked away in red blood cell morphology. We also use the device to separate the parasites that cause sleeping sickness from blood.

Department/s

  • Solid State Physics
  • NanoLund

Publishing year

2010-12-01

Language

English

Pages

1343-1345

Publication/Series

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

Volume

2

Document type

Conference paper

Topic

  • Biomedical Laboratory Science/Technology

Keywords

  • Deterministic lateral displacement
  • Erythrocytes
  • Morphology
  • Separation
  • Trypanosomiasis

Conference name

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

Conference date

2010-10-03 - 2010-10-07

Conference place

Groningen, Netherlands

Status

Published

ISBN/ISSN/Other

  • ISBN: 9781618390622