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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Melting mapping in nanochannels

Author

  • Walter W. Reisner
  • Henrik Flyvbjerg
  • Jonas O. Tegenfeldt

Summary, in English

We demonstrate direct visualization of melting mapping of DNA stretched in nanoscale channels[1] using standard staining methods and epifluorescence microscopy to gain information on the local AT/GC ratio along large DNA molecules. Our development opens up a novel route to mapping of large-scale genomic variations.

Department/s

  • Solid State Physics

Publishing year

2008-01-01

Language

English

Pages

1516-1518

Document type

Conference paper

Keywords

  • DNA
  • Genomics
  • Melting
  • Nanofluidics

Conference name

12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Conference date

2008-10-12 - 2008-10-16

Conference place

San Diego, CA, United States

Status

Published