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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Separation of pathogenic bacteria by chain length

Author

  • Jason P. Beech
  • Bao Dang Ho
  • Geneviève Garriss
  • Vitor Oliveira
  • Birgitta Henriques-Normark
  • Jonas O. Tegenfeldt

Summary, in English

Using Deterministic Lateral Displacement devices optimized for sensitivity to particle length, we separate subpopulations of bacteria depending on known properties that affect their capability to cause disease (virulence). For the human bacterial pathogen Streptococcus pneumoniae, bacterial chain length and the presence of a capsule are known virulence factors contributing to its ability to cause severe disease. Separation of cultured pneumococci into subpopulations based on morphological type (single cocci, diplococci and chains) will enable more detailed studies of the role they play in virulence. Moreover, we present separation of mixed populations of almost genetically identical encapsulated and non-encapsulated pneumococcal strains in our device.

Department/s

  • Solid State Physics
  • NanoLund

Publishing year

2018

Language

English

Pages

223-231

Publication/Series

Analytica Chimica Acta

Volume

1000

Document type

Journal article

Publisher

Elsevier

Topic

  • Microbiology in the medical area

Keywords

  • Bacterial virulence
  • Deterministic lateral displacement
  • Morphology
  • Separation

Status

Published

ISBN/ISSN/Other

  • ISSN: 0003-2670