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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Sorting breast cancer cells based on deformability

Author

  • Si Hoai Trung Tran
  • Bao Dang Ho
  • Stefan Holm
  • Jason P. Beech
  • Jonas O. Tegenfeldt

Summary, in English

Due to their direct coupling to the physiology of the cells, the physical properties are especially attractive as markers for sorting and characterization of cancer cells. Where molecular surface markers are lacking, the physical properties can instead serve as inherent markers for separation. This is especially interesting for cancer cells where there are indications that soft cells are more metastatic than hard cells. Our work is expected to provide a deeper understanding of deformability based sorting based on deterministic lateral displacement (DLD). This will subsequently be used to optimize DLD devices for characterization and fractionation of cancer cells into subpopulations of different mechanical properties. Our aim is to develop a device to help oncologists gain more accurate prognoses and better monitoring of the effect of treatment.

Department/s

  • Solid State Physics
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2015

Language

English

Pages

364-366

Publication/Series

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Document type

Conference paper

Publisher

Chemical and Biological Microsystems Society

Topic

  • Biomedical Laboratory Science/Technology
  • Cancer and Oncology

Keywords

  • Cancer
  • Cell mechanics
  • Deterministic lateral displacement

Conference name

19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015

Conference date

2015-10-25 - 2015-10-29

Conference place

Gyeongju, Korea, Republic of

Status

Published

ISBN/ISSN/Other

  • ISBN: 9780979806483