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Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Jonas Tegenfeldt

Professor, Coordinator Nanobiology & Neuronanoscience

Portrait of Jonas Tegenfeldt. Photo: Kennet Ruona

Sorting red blood cells by their dynamical properties

Author

  • Ewan Henry
  • S. H. Holm
  • Z. Zhang
  • J. P. Beech
  • J. O. Tegenfeldt
  • Dmitry A. Fedosov
  • Gerhard Gompper

Summary, in English

A combination of mesoscale hydrodynamic simulations and microfluidic experiments are used to explore the use of cells' mechanical and dynamical properties as biomarkers for separation. Dynamic behaviour of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated within various array geometries and for different viscosity contrasts between the intra- and extra-cellular fluid. We find that the viscosity contrast and associated cell dynamics clearly determine RBC trajectories through DLD devices. Simulation results compare well to experiments and provide new insights into the physical mechanisms which govern the sorting of non-spherical and deformable cells in DLD devices.

Department/s

  • Solid State Physics
  • NanoLund

Publishing year

2016

Language

English

Pages

786-787

Publication/Series

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Document type

Conference paper

Publisher

Chemical and Biological Microsystems Society

Topic

  • Cell and Molecular Biology
  • Medical Laboratory and Measurements Technologies

Keywords

  • Cell dynamics
  • Cell sorting
  • Deterministic lateral displacement
  • Red blood cell

Conference name

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Conference date

2016-10-09 - 2016-10-13

Conference place

Dublin, Ireland

Status

Published

ISBN/ISSN/Other

  • ISBN: 9780979806490