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Maria Thereza Perez

Senior Lecturer

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Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues


  • T Oohashi
  • Xiaohong Zhou
  • Kang Feng
  • B Richter
  • Matthias Mörgelin
  • Maria Thereza Perez
  • W D Su
  • R Chiquet-Ehrismann
  • Uwe Rauch
  • Reinhard Fässler

Summary, in English

The Drosophila gene ten-m/odz is the only pair rule gene identified to date which is not a transcription factor. In an attempt to analyze the structure and the function of ten-m/odz in mouse, we isolated four murine ten-m cDNAs which code for proteins of 2,700-2, 800 amino acids. All four proteins (Ten-m1-4) lack signal peptides at the NH2 terminus, but contain a short hydrophobic domain characteristic of transmembrane proteins, 300-400 amino acids after the NH2 terminus. About 200 amino acids COOH-terminal to this hydrophobic region are eight consecutive EGF-like domains. Cell transfection, biochemical, and electronmicroscopic studies suggest that Ten-m1 is a dimeric type II transmembrane protein. Expression of fusion proteins composed of the NH2-terminal and hydrophobic domain of ten-m1 attached to the alkaline phosphatase reporter gene resulted in membrane-associated staining of the alkaline phosphatase. Electronmicroscopic and electrophoretic analysis of a secreted form of the extracellular domain of Ten-m1 showed that Ten-m1 is a disulfide-linked dimer and that the dimerization is mediated by EGF-like modules 2 and 5 which contain an odd number of cysteines. Northern blot and immunohistochemical analyses revealed widespread expression of mouse ten-m genes, with most prominent expression in brain. All four ten-m genes can be expressed in variously spliced mRNA isoforms. The extracellular domain of Ten-m1 fused to an alkaline phosphatase reporter bound to specific regions in many tissues which were partially overlapping with the Ten-m1 immunostaining. Far Western assays and electronmicroscopy demonstrated that Ten-m1 can bind to itself.


  • Tumor microenvironment
  • Infection Medicine (BMC)
  • Ophthalmology, Lund
  • Vessel Wall Biology

Publishing year







Journal of Cell Biology





Document type

Journal article


Rockefeller University Press


  • Cancer and Oncology
  • Ophthalmology
  • Infectious Medicine
  • Cell and Molecular Biology


  • epidermal growth factor
  • pair rule
  • ten-m/odz
  • transmembrane protein



Research group

  • Vessel Wall Biology


  • ISSN: 0021-9525