Sara Linse

A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ₄₂ Aggregation

Kevin N. Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias Schneider, Oded Rimon, et al.
(2023) ACS Chemical Neuroscience, 14 p.323-329
Journal article

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, et al.
(2023) Molecular Pharmaceutics, 20 p.183-193
Journal article

Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation

Dev Thacker, Amanda Willas, Alexander J. Dear, Sara Linse
(2022) ACS Chemical Neuroscience, 13 p.3477-3487
Journal article

Influence of denaturants on amyloid β42 aggregation kinetics

Tanja Weiffert, Georg Meisl, Samo Curk, Risto Cukalevski, Anđela Šarić, et al.
(2022) Frontiers in Neuroscience, 16
Journal article

α-Synuclein Interaction with Lipid Bilayer Discs

Marija Dubackic, Yun Liu, Elizabeth G. Kelley, Crispin Hetherington, Michael Haertlein, et al.
(2022) Langmuir, 38 p.10216-10224
Journal article

Uncovering the universality of self-replication in protein aggregation and its link to disease

Georg Meisl, Catherine K. Xu, Jonathan D. Taylor, Thomas C. T. Michaels, Aviad Levin, et al.
(2022) Science Advances, 8
Journal article

An aggregation inhibitor specific to oligomeric intermediates of Aβ42 derived from phage display libraries of stable, small proteins

Sara Linse, Pietro Sormanni, David J. O’Connell
(2022) Proceedings of the National Academy of Sciences of the United States of America, 119
Journal article

Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation

Gabriel A. Braun, Alexander J. Dear, Kalyani Sanagavarapu, Henrik Zetterberg, Sara Linse
(2022) Chemical Science, 13 p.2423-2439
Journal article

A Palette of Fluorescent Aβ42 Peptides Labelled at a Range of Surface-Exposed Sites

Dev Thacker, Mara Bless, Mohammad Barghouth, Enming Zhang, Sara Linse
(2022) International Journal of Molecular Sciences, 23
Journal article

High-Efficiency Expression and Purification of DNAJB6b Based on the pH-Modulation of Solubility and Denaturant-Modulation of Size

Sara Linse
(2022) Molecules, 27
Journal article

¹H detection and dynamic nuclear polarization–enhanced NMR of Aβ_1-42 fibrils

Salima Bahri, Robert Silvers, Brian Michael, Kristaps Jaudzems, Daniela Lalli, et al.
(2022) Proceedings of the National Academy of Sciences of the United States of America, 119
Journal article

α-Synuclein-induced deformation of small unilamellar vesicles

Katarzyna Makasewicz, Stefan Wennmalm, Sara Linse, Emma Sparr
(2022) QRB Discovery, 3
Journal article

On the Aggregation of Apolipoprotein A-I

Rebecca Frankel, Emma Sparr, Sara Linse
(2022) International Journal of Molecular Sciences, 23
Journal article

Comparing α-Synuclein Fibrils Formed in the Absence and Presence of a Model Lipid Membrane : A Small and Wide-Angle X-Ray Scattering Study

Marija Dubackic, Sara Linse, Emma Sparr, Ulf Olsson
(2022) Frontiers in Soft Matter, 1
Journal article

Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation

Diana C. Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, et al.
(2021) ACS Chemical Neuroscience, 12 p.4406-4415
Journal article

The bacterial amyloids phenol soluble modulins from staphylococcus aureus catalyze alpha-synuclein aggregation

Caroline Haikal, Lei Ortigosa Pascual, Zahra Najarzadeh, Katja Bernfur, Alexander Svanbergsson, et al.
(2021) International Journal of Molecular Sciences, 22
Journal article

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

Diana C. Rodriguez Camargo, Sean Chia, Joseph Menzies, Benedetta Mannini, Georg Meisl, et al.
(2021) Frontiers in Molecular Biosciences, 8
Journal article

Amyloid β 42 fibril structure based on small-angle scattering

Veronica Lattanzi, Ingemar Andre, Urs Gasser, Marija Dubackic, Ulf Olsson, et al.
(2021) Proceedings of the National Academy of Sciences of the United States of America, 118
Journal article

On the Cluster Formation of α-Synuclein Fibrils

Marija Dubackic, Ilaria Idini, Veronica Lattanzi, Yun Liu, Anne Martel, et al.
(2021) Frontiers in Molecular Biosciences, 8
Journal article

Toward the equilibrium and kinetics of amyloid peptide self-assembly

Sara Linse
(2021) Current Opinion in Structural Biology, 70 p.87-98
Journal article review

Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation

Manuela R. Zimmermann, Subhas C. Bera, Georg Meisl, Sourav Dasadhikari, Shamasree Ghosh, et al.
(2021) Journal of the American Chemical Society, 143 p.16621-16629
Journal article

The unhappy chaperone

Sara Linse, Kyrre Thalberg, Tuomas P.J. Knowles
(2021) QRB Discovery, 2
Journal article

Charge Regulation during Amyloid Formation of α-Synuclein

Tinna Pálmadóttir, Anders Malmendal, Thom Leiding, Mikael Lund, Sara Linse
(2021) Journal of the American Chemical Society, 143 p.7777-7791
Journal article

Expression, purification and characterisation of large quantities of recombinant human IAPP for mechanistic studies

Martin Lundqvist, Diana C. Rodriguez Camargo, Katja Bernfur, Sean Chia, Sara Linse
(2021) Biophysical Chemistry, 269
Journal article

Guest-protein incorporation into solvent channels of a protein host crystal (hostal)

Janina Sprenger, Jannette Carey, Alexander Schulz, Fleur Drouard, Catherine L. Lawson, et al.
(2021) Acta Crystallographica Section D: Structural Biology, 77 p.471-485
Journal article

Calmodulin complexes with brain and muscle creatine kinase peptides

Janina Sprenger, Anda Trifan, Neal Patel, Ashley Vanderbeck, Jenny Bredfelt, et al.
(2021) Current Research in Structural Biology, 3 p.121-132
Journal article

Cooperativity of α-Synuclein Binding to Lipid Membranes

Katarzyna Makasewicz, Stefan Wennmalm, Björn Stenqvist, Marco Fornasier, Alexandra Andersson, et al.
(2021) ACS Chemical Neuroscience, 12 p.2099-2109
Journal article

Transient Lipid-Protein Structures and Selective Ganglioside Uptake During α-Synuclein-Lipid Co-aggregation

Ricardo Gaspar, Ilaria Idini, Göran Carlström, Sara Linse, Emma Sparr
(2021) Frontiers in cell and developmental biology, 9
Journal article

pH-Responsive Capsules with a Fibril Scaffold Shell Assembled from an Amyloidogenic Peptide

Ulyana Shimanovich, Aviad Levin, Dror Eliaz, Thomas Michaels, Zenon Toprakcioglu, et al.
(2021) Small
Journal article

Chiral Selectivity of Secondary Nucleation in Amyloid Fibril Propagation

Mattias Törnquist, Sara Linse
(2021) Angewandte Chemie - International Edition, 60 p.24008-24011
Journal article

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, et al.
(2021) Communications Biology, 4
Journal article

Solubility of Aβ40 peptide

Veronica Lattanzi, Katja Bernfur, Emma Sparr, Ulf Olsson, Sara Linse
(2021) JCIS Open, 4
Journal article

Purification and HDL-like particle formation of apolipoprotein A-I after co-expression with the EDDIE mutant of Npro autoprotease

Rebecca Frankel, Katja Bernfur, Emma Sparr, Sara Linse
(2021) Protein Expression and Purification, 187
Journal article

On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide

Gabriel A. Braun, Beatrice E. Ary, Alexander J. Dear, Matthew C.H. Rohn, Abigail M. Payson, et al.
(2020) Biomacromolecules, 21 p.4781-4794
Journal article

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

Sara Linse, Tom Scheidt, Katja Bernfur, Michele Vendruscolo, Christopher M. Dobson, et al.
(2020) Nature Structural and Molecular Biology, 27 p.1125-1133
Journal article

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

Patrick Flagmeier, Suman De, Thomas C.T. Michaels, Xiaoting Yang, Alexander J. Dear, et al.
(2020) Nature Structural and Molecular Biology, 27 p.886-891
Journal article

Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

Thomas C.T. Michaels, Andela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, et al.
(2020) Proceedings of the National Academy of Sciences of the United States of America, 117 p.24251-24257
Journal article

Anomalous Salt Dependence Reveals an Interplay of Attractive and Repulsive Electrostatic Interactions in α-synuclein Fibril Formation

Ricardo Gaspar, Mikael Lund, Emma Sparr, Sara Linse
(2020) Quarterly Reviews in Biophysics Discovery, 1
Journal article

Ultrastructural evidence for self-replication of alzheimer-associated Aβ42 amyloid along the sides of fibrils

Mattias Tornquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P.J. Knowles, et al.
(2020) Proceedings of the National Academy of Sciences of the United States of America, 117 p.11265-11273
Journal article

The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain

Alessia Peduzzo, Sara Linse, Alexander K. Buell
(2020) ACS Chemical Neuroscience, 11 p.909-918
Journal article

The catalytic nature of protein aggregation

Alexander J. Dear, Georg Meisl, Thomas C.T. Michaels, Manuela R. Zimmermann, Sara Linse, et al.
(2020) Journal of Chemical Physics, 152
Journal article

Single Step Purification of Glycogen Synthase Kinase Isoforms from Small Scale Transient Expression in HEK293 Cells with a Calcium-Dependent Fragment Complementation System

Gavin McGauran, Sara Linse, David J. O'Connell
(2020) Methods in molecular biology (Clifton, N.J.), 2095 p.385-396
Journal article

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

Roxine Staats, Thomas C.T. Michaels, Patrick Flagmeier, Sean Chia, Robert I. Horne, et al.
(2020) Communications Chemistry, 3
Journal article

A microfluidic strategy for the detection of membrane protein interactions

Yuewen Zhang, Therese W. Herling, Stefan Kreida, Quentin A.E. Peter, Tadas Kartanas, et al.
(2020) Lab on a Chip, 20 p.3230-3238
Journal article

Expression and Purification of Intrinsically Disordered Aβ Peptide and Setup of Reproducible Aggregation Kinetics Experiment

Sara Linse
(2020) Methods in molecular biology (Clifton, N.J.), 2141 p.731-754
Journal article

Kinetic diversity of amyloid oligomers

Alexander J. Dear, Thomas C.T. Michaels, Georg Meisl, David Klenerman, Si Wu, et al.
(2020) Proceedings of the National Academy of Sciences of the United States of America, 117
Journal article

Identification of on- And off-pathway oligomers in amyloid fibril formation

Alexander J. Dear, Georg Meisl, Anđela Šarić, Thomas C.T. Michaels, Magnus Kjaergaard, et al.
(2020) Chemical Science, 11 p.6236-6247
Journal article

Benefits and constrains of covalency : the role of loop length in protein stability and ligand binding

Sara Linse, Eva Thulin, Hanna Nilsson, Johannes Stigler
(2020) Scientific Reports, 10
Journal article

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

Dev Thacker, Kalyani Sanagavarapu, Birgitta Frohm, Georg Meisl, Tuomas P.J. Knowles, et al.
(2020) Proceedings of the National Academy of Sciences of the United States of America, 117 p.25272-25283
Journal article

Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

Thomas C.T. Michaels, Andela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio, et al.
(2020) Nature Chemistry, 12 p.445-451
Journal article

Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

Céline Galvagnion, Daniel Topgaard, Katarzyna Makasewicz, Alexander K. Buell, Sara Linse, et al.
(2019) Journal of Physical Chemistry Letters, 10 p.7872-7877
Journal article

Trodusquemine enhances Aβ₄₂ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Ryan Limbocker, Sean Chia, Francesco S. Ruggeri, Michele Perni, Roberta Cascella, et al.
(2019) Nature Communications, 10
Journal article

Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties

Brett H. Pogostin, Sara Linse, Ulf Olsson
(2019) Langmuir, 35 p.16536-16544
Journal article

Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data

Kristine Steen Jensen, Sara Linse, Mathias Nilsson, Mikael Akke, Anders Malmendal
(2019) Journal of the American Chemical Society, 141 p.18649-18652
Journal article

The molecular basis of human igg-mediated enhancement of C4b-binding protein recruitment to group a streptococcus

David Ermert, Maisem Laabei, Antonin Weckel, Matthias Mörgelin, Martin Lundqvist, et al.
(2019) Frontiers in Immunology, 10
Journal article

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, et al.
(2019) Acta Neuropathologica, 138 p.251-273
Journal article

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

Kalyani Sanagavarapu, Elisabeth Nüske, Irem Nasir, Georg Meisl, Jasper N. Immink, et al.
(2019) Scientific Reports, 9
Journal article

Charting a course for chemistry

A. Aspuru-Guzik, Sara Linse, H. Zhang
(2019) Nature Chemistry, 11 p.286-294
Journal article (comment)

Mechanism of amyloid protein aggregation and the role of inhibitors

Sara Linse
(2019) Pure and Applied Chemistry, 91 p.211-229
Journal article

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-b aggregates

Tom Scheidt, Urszula Łapińska, Janet R. Kumita, Daniel R. Whiten, David Klenerman, et al.
(2019) Science Advances, 5
Journal article

Lipid-protein interactions in amyloid formation

Emma Sparr, Sara Linse
(2019) Biochimica et Biophysica Acta - Proteins and Proteomics, 1867 p.455-457
Journal article (comment)

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42

Tanja Weiffert, Georg Meisl, Patrick Flagmeier, Suman De, Christopher J.R. Dunning, et al.
(2019) ACS Chemical Neuroscience
Journal article

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

Rebecca Frankel, Mattias Törnquist, Georg Meisl, Oskar Hansson, Ulf Andreasson, et al.
(2019) Communications Biology, 2
Journal article

Ganglioside lipids accelerate α-synuclein amyloid formation

Ricardo Gaspar, Jon Pallbo, Ulrich Weininger, Sara Linse, Emma Sparr
(2018) Biochimica et Biophysica Acta - Proteins and Proteomics, 1866 p.1062-1072
Journal article

Disaggregation of gold nanoparticles by Daphnia magna

Karin Mattsson, Ruben Aguilar, Oscar Torstensson, Diana Perry, Katja Bernfur, et al.
(2018) Nanotoxicology, 12 p.885-900
Journal article

Protein stabilization with retained function of monellin using a split GFP system

Tanja Weiffert, Sara Linse
(2018) Scientific Reports, 8
Journal article

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

Xiaoting Yang, Georg Meisl, Birgitta Frohm, Eva Thulin, Tuomas P.J. Knowles, et al.
(2018) Proceedings of the National Academy of Sciences of the United States of America, 115 p.5849-5858
Journal article

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

Johnny Habchi, Sean Chia, Céline Galvagnion, Thomas C.T. Michaels, Mathias M.J. Bellaiche, et al.
(2018) Nature Chemistry, 10 p.673-683
Journal article

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

Samuel I.A. Cohen, Risto Cukalevski, Thomas C.T. Michaels, A. Šarić, Mattias Törnquist, et al.
(2018) Nature Chemistry, 10 p.523-531
Journal article

Conformational Ensembles of Calmodulin Revealed by Nonperturbing Site-Specific Vibrational Probe Groups

Kristen L. Kelly, Shannon R. Dalton, Rebecca B. Wai, Kanika Ramchandani, Rosalind J. Xu, et al.
(2018) Journal of Physical Chemistry A, 122 p.2947-2955
Journal article

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces

Giulio Tesei, Erik Hellstrand, Kalyani Sanagavarapu, Sara Linse, Emma Sparr, et al.
(2018) Langmuir, 34 p.1266-1273
Journal article

Production and use of recombinant Aβ for aggregation studies

Tiernan T. O’Malley, Sara Linse, Dominic M. Walsh
(2018) Methods in Molecular Biology, 1777 p.307-320
Book chapter

Kinetic analysis of amyloid formation

Georg Meisl, Thomas C.T. Michaels, Sara Linse, Tuomas P.J. Knowles
(2018) Methods in Molecular Biology, 1779 p.181-196
Book chapter

Protein-protein interactions in AQP regulation - biophysical characterization of AQP0-CaM and AQP2-LIP5 complex formation

Stefan Kreida*, Jennifer Roche*, Caroline Olsson, Sara Linse, Susanna Horsefield
(2018) Faraday Discussions, 209 p.35-54
Journal article

SAR by kinetics for drug discovery in protein misfolding diseases

Sean Chia, Johnny Habchi, Thomas C.T. Michaels, Samuel I.A. Cohen, Sara Linse, et al.
(2018) Proceedings of the National Academy of Sciences of the United States of America, 115 p.10245-10250
Journal article

Secondary nucleation in amyloid formation

Mattias Törnquist, Thomas C.T. Michaels, Kalyani Sanagavarapu, Xiaoting Yang, Georg Meisl, et al.
(2018) Chemical Communications, 54 p.8667-8684
Journal article

Proton-Assisted Recoupling (PAR) in Peptides and Proteins

Kevin J. Donovan, Sheetal K. Jain, Robert Silvers, Sara Linse, Robert G. Griffin
(2017) Journal of Physical Chemistry B, 121 p.10804-10817
Journal article

Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain

Karin Mattsson, Elyse V. Johnson, Anders Malmendal, Sara Linse, Lars Anders Hansson, et al.
(2017) Scientific Reports, 7
Journal article

Cu/Zn Superoxide Dismutase Forms Amyloid Fibrils under Near-Physiological Quiescent Conditions : The Roles of Disulfide Bonds and Effects of Denaturant

Ashhar Khan, Michal Respondek, Sven Kjellström, Shashank Deep, Sara Linse, et al.
(2017) ACS Chemical Neuroscience, 8 p.2019-2026
Journal article

Aggregation and Fibril Structure of Aβ_M01-42 and Aβ_1-42

Robert Silvers, Michael T Colvin, Kendra K. Frederick, Angela C Jacavone, Susan Lindquist, et al.
(2017) Biochemistry, 56 p.4850-4859
Journal article

Monomer-dependent secondary nucleation in amyloid formation

Sara Linse
(2017) Biophysical Reviews, 9 p.329-338
Journal article review

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

Sean Chia, Patrick Flagmeier, Johnny Habchi, Veronica Lattanzi, Sara Linse, et al.
(2017) Proceedings of the National Academy of Sciences of the United States of America, 114 p.8005-8010
Journal article

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

Anna Munke, Jonas Persson, Tanja Weiffert, Erwin J. De Genst, Georg Meisl, et al.
(2017) Proceedings of the National Academy of Sciences of the United States of America, 114 p.6444-6449
Journal article

Selective targeting of primary and secondary nucleation pathways in Ab42 aggregation using a rational antibody scanning method

Francesco A. Aprile, Pietro Sormanni, Michele Perni, Paolo Arosio, Sara Linse, et al.
(2017) Science Advances, 3
Journal article

3D MAS NMR Experiment Utilizing Through-Space ¹⁵N-¹⁵N Correlations

Kevin J. Donovan, Robert Silvers, Sara Linse, Robert G Griffin
(2017) Journal of the American Chemical Society, 139 p.6518-6521
Journal article

The nanoparticle protein corona formed in human blood or human blood fractions

Martin Lundqvist, Cecilia Augustsson, Malin Lilja, Kristoffer Lundkvist, Björn Dahlbäck, et al.
(2017) PLoS ONE, 12
Journal article

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

Johnny Habchi, Sean Chia, Ryan Limbocker, Benedetta Mannini, Minkoo Ahn, et al.
(2017) Proceedings of the National Academy of Sciences of the United States of America, 114 p.200-208
Journal article

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

Ricardo Gaspar, Georg Meisl, Alexander K. Buell, Laurence Young, Clemens F. Kaminski, et al.
(2017) Quarterly Reviews of Biophysics, 50
Journal article

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

Georg Meisl, Xiaoting Yang, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
(2017) Chemical Science, 8 p.4352-4362
Journal article

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products

Kadi L. Saar, Yingbo Zhang, Thomas Müller, Challa P. Kumar, Sean Devenish, et al.
(2017) Lab on a Chip, 18 p.162-170
Journal article

Scaling behaviour and rate-determining steps in filamentous self-assembly

Georg Meisl, Luke Rajah, Samuel I A Cohen, Manuela Pfammatter, Andela Šarić, et al.
(2017) Chemical Science, 8 p.7087-7097
Journal article

Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele

E. R. Padayachee, H. Zetterberg, E. Portelius, J. Borén, J. L. Molinuevo, et al.
(2016) Brain Research, 1651 p.11-16
Journal article

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer

Tiernan T. O'Malley, William M. Witbold, Sara Linse, Dominic M. Walsh
(2016) Biochemistry, 55 p.6150-6161
Journal article

Calcium binding and disulfide bonds regulate the stability of Secretagogin towards thermal and urea denaturation

Kalyani Sanagavarapu, Tanja Weiffert, Niamh Ní Mhurchú, David O'Connell, Sara Linse
(2016) PLoS ONE, 11
Journal article

Translocation of 40 nm diameter nanowires through the intestinal epithelium of Daphnia magna

Karin Mattsson, Karl Adolfsson, Mikael T. Ekvall, Magnus T. Borgström, Sara Linse, et al.
(2016) Nanotoxicology, 10 p.1160-1167
Journal article

Physical determinants of the self-replication of protein fibrils

Andela Šaric, Alexander K. Buell, Georg Meisl, Thomas C T Michaels, Christopher M. Dobson, et al.
(2016) Nature Physics, 12 p.874-880
Journal article

Atomic Resolution Structure of Monomorphic Aβ₄₂ Amyloid Fibrils

Michael T. Colvin, Robert Silvers, Qing Zhe Ni, Thach V. Can, Ivan Sergeyev, et al.
(2016) Journal of the American Chemical Society, 138 p.9663-9674
Journal article

Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation

Paolo Arosio, Tommy Cedervall, Tuomas P J Knowles, Sara Linse
(2016) Analytical Biochemistry, 504 p.7-13
Journal article

A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions

Therese W. Herling, David J. O'Connell, Mikael C. Bauer, Jonas Persson, Ulrich Weininger, et al.
(2016) Biophysical Journal, 110 p.1957-1966
Journal article

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

Vaishali Kakkar, Cecilia Månsson, Eduardo P. de Mattos, Steven Bergink, Marianne van der Zwaag, et al.
(2016) Molecular Cell, 62 p.272-283
Journal article

Mathematical modeling of the protein corona : Implications for nanoparticulate delivery systems

Daniele Dell'Orco, Martin Lundqvist, Sara Linse, Tommy Cedervall
(2016) Handbook of Immunological Properties of Engineered Nanomaterials: : Haematocompatibility of Engineered Nanomaterials, 2 p.53-65
Book chapter

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

Paolo Arosio, Thomas C T Michaels, Sara Linse, Cecilia Månsson, Cecilia Emanuelsson, et al.
(2016) Nature Communications, 7
Journal article

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Georg Meisl, Julius B Kirkegaard, Paolo Arosio, Thomas C T Michaels, Michele Vendruscolo, et al.
(2016) Nature Protocols, 11 p.252-272
Journal article

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.

Paolo Arosio, Thomas Müller, Luke Rajah, Emma V Yates, Francesco A Aprile, et al.
(2016) ACS Nano, 10 p.333-341
Journal article

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.

Johnny Habchi, Paolo Arosio, Michele Perni, Ana Rita Costa, Maho Yagi-Utsumi, et al.
(2016) Science Advances, 2
Journal article

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.

Georg Meisl, Xiaoting Yang, Birgitta Frohm, Tuomas P J Knowles, Sara Linse
(2016) Scientific Reports, 6
Journal article

A microfluidic platform for quantitative measurements of effective protein charges and single ion binding in solution

Therese W. Herling, Paolo Arosio, Thomas Mueller, Sara Linse, Tuomas P. J. Knowles
(2015) Physical Chemistry Chemical Physics, 17 p.12161-12167
Journal article

Altered Behavior, Physiology, and Metabolism in Fish Exposed to Polystyrene Nanoparticles

Karin Mattsson, Mikael T. Ekvall, Lars-Anders Hansson, Sara Linse, Anders Malmendal, et al.
(2015) Environmental Science & Technology, 49 p.553-561
Journal article

On the lag phase in amyloid fibril formation

Paolo Arosio, Tuomas P. J. Knowles, Sara Linse
(2015) Physical Chemistry Chemical Physics, 17 p.7606-7618
Journal article

Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

Mads T. Sondergaard, Anders B. Sorensen, Louise L. Skov, Kasper Kjaer-Sorensen, Mikael Bauer, et al.
(2015) The FEBS Journal, 282 p.803-816
Journal article

High Resolution Structural Characterization of A beta(42) Amyloid Fibrils by Magic Angle Spinning NMR

Michael T. Covin, Robert Silvers, Birgitta Frohm, Yongchao Su, Sara Linse, et al.
(2015) Journal of the American Chemical Society, 137 p.7509-7518
Journal article

Fluorescent Filter-Trap Assay for Amyloid Fibril Formation Kinetics in Complex Solutions.

Irem Nasir, Sara Linse, Celia Cabaleiro-Lago
(2015) ACS Chemical Neuroscience, 6 p.1436-1444
Journal article

Haemophilus influenzae surface fibril (Hsf) is a unique twisted hairpin-like trimeric autotransporter

Birendra Singh, Tamim Al Jubair, Matthias Mörgelin, Anders Sundin, Sara Linse, et al.
(2015) International Journal of Medical Microbiology, 305 p.27-37
Journal article

Protein Microgels from Amyloid Fibril Networks

Ulyana Shimanovich, Igor Efimov, Thomas O. Mason, Patrick Flagmeier, Alexander K. Buell, et al.
(2015) ACS Nano, 9 p.43-51
Journal article

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42.

Olga Szczepankiewicz, Björn Linse, Georg Meisl, Eva Thulin, Birgitta Frohm, et al.
(2015) Journal of the American Chemical Society, 137 p.14673-14685
Journal article

The A beta 40 and A beta 42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation

Risto Cukalevski, Xiaoting Yang, Georg Meisl, Ulrich Weininger, Katja Bernfur, et al.
(2015) Chemical Science, 6 p.4215-4233
Journal article

Site-Specific Protonation Kinetics of Acidic Side Chains in Proteins Determined by pH-Dependent Carboxyl (13)C NMR Relaxation.

Johan Wallerstein, Ulrich Weininger, Ashhar Khan, Sara Linse, Mikael Akke
(2015) Journal of the American Chemical Society, 137 p.3093-3101
Journal article

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

Emma V. Yates, Thomas Mueller, Luke Rajah, Erwin J. De Genst, Paolo Arosio, et al.
(2015) Nature Chemistry, 7 p.802-809
Journal article

Digested wheat gluten inhibits binding between leptin and its receptor

Tommy Jönsson, Ashfaque Memon, Kristina Sundquist, Jan Sundquist, Stefan Olsson, et al.
(2015) BMC Biochemistry, 16
Journal article

High Throughput Screening Method to Explore Protein Interactions with Nanoparticles.

Irem Nasir, Warda Fatih, Anja Svensson, Dennis Radu, Sara Linse, et al.
(2015) PLoS ONE, 10
Journal article

A beta dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

Tiernan T. O'Malley, Nur Alia Oktaviani, Dainan Zhang, Aleksey Lomakin, Brian O'Nuallain, et al.
(2014) Biochemical Journal, 461 p.413-426
Journal article

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.

Cecilia Månsson, Paolo Arosio, Rasha Hussein, Harm H Kampinga, Reem M Hashem, et al.
(2014) Journal of Biological Chemistry, 289 p.31066-31076
Journal article

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-beta peptide in Drosophila melanogaster

Erik Hermansson, Sebastian Schultz, Damian Crowther, Sara Linse, Bengt Winblad, et al.
(2014) Disease Models and Mechanisms, 7 p.659-665
Journal article

Size-Dependent Effects of Nanoparticles on Enzymes in the Blood Coagulation Cascade.

Elodie Sanfins, Cecilia Augustsson, Björn Dahlbäck, Sara Linse, Tommy Cedervall
(2014) Nano Letters, 14 p.4736-4744
Journal article

Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation

Alexander K. Buell, Celine Galvagnion, Ricardo Gaspar, Emma Sparr, Michele Vendruscolo, et al.
(2014) Proceedings of the National Academy of Sciences, 111 p.7671-7676
Journal article

Effects of Polyamino Acids and Polyelectrolytes on Amyloid β Fibril Formation.

Anna Assarsson, Sara Linse, Celia Cabaleiro-Lago
(2014) Langmuir, 30 p.8812-8818
Journal article

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.

Georg Meisl, Xiaoting Yang, Erik Hellstrand, Birgitta Frohm, Julius B Kirkegaard, et al.
(2014) Proceedings of the National Academy of Sciences, 111 p.9384-9389
Journal article

Mathematical modeling of the protein corona: implications for nanoparticulate delivery systems

Daniele Dell'Orco, Martin Lundqvist, Sara Linse, Tommy Cedervall
(2014) Nanomedicine, 9 p.851-858
Journal article

Surface Effects on Aggregation Kinetics of Amyloidogenic Peptides

Robert Vacha, Sara Linse, Mikael Lund
(2014) Journal of the American Chemical Society, 136 p.11776-11782
Journal article

Charge Dependent Retardation of Amyloid beta Aggregation by Hydrophilic Proteins

Anna Assarsson, Erik Hellstrand, Celia Cabaleiro-Lago, Sara Linse
(2014) ACS Chemical Neuroscience, 5 p.266-274
Journal article

Quantification of the Concentration of A beta 42 Propagons during the Lag Phase by an Amyloid Chain Reaction Assay

Paolo Arosio, Risto Cukalevski, Birgitta Frohm, Tuomas P. J. Knowles, Sara Linse
(2014) Journal of the American Chemical Society, 136 p.219-225
Journal article

Adsorption of α-Synuclein to Supported Lipid Bilayers: Positioning and Role of Electrostatics.

Erik Hellstrand, Marie Grey, Marie-Louise Ainalem, John Ankner, V Trevor Forsyth, et al.
(2013) ACS Chemical Neuroscience, 4 p.1339-1351
Journal article

Three-dimensional tracking of small aquatic organisms using fluorescent nanoparticles.

Mikael Ekvall, Giuseppe Bianco, Sara Linse, Heiner Linke, Johan Bäckman, et al.
(2013) PLoS ONE, 8
Journal article

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils.

Erik Hellstrand, Agnieszka Nowacka, Daniel Topgaard, Sara Linse, Emma Sparr
(2013) PLoS ONE, 8
Journal article

Calmodulin Transduces Ca2+ Oscillations into Differential Regulation of Its Target Proteins

Nikolai Slavov, Jannette Carey, Sara Linse
(2013) ACS Chemical Neuroscience, 4 p.601-612
Journal article

Förster resonance energy transfer studies of calmodulin produced by native protein ligation reveal inter-domain electrostatic repulsion.

Erik Hellstrand, Stephanie Kukora, Cynthia Shuman, Sara Steenbergen, Eva Thulin, et al.
(2013) The FEBS Journal, 280 p.2675-2687
Journal article

The BRICHOS Domain, Amyloid Fibril Formation, and Their Relationship

Stefan D. Knight, Jenny Presto, Sara Linse, Jan Johansson
(2013) Biochemistry, 52 p.7523-7531
Journal article

Proliferation of amyloid-beta 42 aggregates occurs through a secondary nucleation mechanism

Samuel I. A. Cohen, Sara Linse, Leila M. Luheshi, Erik Hellstrand, Duncan A. White, et al.
(2013) Proceedings of the National Academy of Sciences, 110 p.9758-9763
Journal article

Obligatoriskt nanoregister? Nej tack!

Åsalie Hartmanis, Mats Bohgard, Heiner Linke, Lars Montelius, Sara Linse, et al.
(2012) Ny teknik
Newspaper article

Biocompatibility of mannan nanogel-safe interaction with plasma proteins

Silvia A. Ferreira, Cecilia Oslakovic, Risto Cukalevski, Birgitta Frohm, Björn Dahlbäck, et al.
(2012) Biochimica et Biophysica Acta. General Subjects, 1820 p.1043-1051
Journal article

Role of Aromatic Side Chains in Amyloid β-Protein Aggregation.

Risto Cukalevski, Barry Boland, Birgitta Frohm, Eva Thulin, Dominic Walsh, et al.
(2012) ACS Chemical Neuroscience, 3 p.1008-1016
Journal article

Food chain transport of nanoparticles affects behaviour and fat metabolism in fish.

Tommy Cedervall, Lars-Anders Hansson, Mercy Lard, Birgitta Frohm, Sara Linse
(2012) PLoS ONE, 7
Journal article

High Affinity Antibodies to Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Malaria

Sreenivasulu B. Reddy, Robin F. Anders, James G. Beeson, Anna Farnert, Fred Kironde, et al.
(2012) PLoS ONE, 7
Journal article

BRICHOS Domains Efficiently Delay Fibrillation of Amyloid beta-Peptide

Hanna Willander, Jenny Presto, Glareh Askarieh, Henrik Biverstal, Birgitta Frohm, et al.
(2012) Journal of Biological Chemistry, 287 p.31608-31617
Journal article

The Effect of Nanoparticles on Amyloid Aggregation Depends on the Protein Stability and Intrinsic Aggregation Rate

Celia Cabaleiro-Lago, Olga Szczepankiewicz, Sara Linse
(2012) Langmuir, 28 p.1852-1857
Journal article

Calcium-Dependent Interaction of Calmodulin with Human 80S Ribosomes and Polyribosomes.

Petra Behnen, Elizabeth Davis, Erin Delaney, Birgitta Frohm, Mikael Bauer, et al.
(2012) Biochemistry, 51 p.6718-6727
Journal article

Dynamics of Conformational Ca2+-Switches in Signaling Networks Detected by a Planar Plasmonic Device

Daniele Dell'Orco, Stefan Sulmann, Sara Linse, Karl-Wilhelm Koch
(2012) Analytical Chemistry, 84 p.2982-2989
Journal article

Delivery success rate of engineered nanoparticles in the presence of the protein corona: a systems-level screening

Daniele Dell'Orco, Martin Lundqvist, Tommy Cedervall, Sara Linse
(2012) Nanomedicine: Nanotechnology, Biology and Medicine, 8 p.1271-1281
Journal article

Specific Binding of a beta-Cyclodextrin Dimer to the Amyloid beta Peptide Modulates the Peptide Aggregation Process

Anna Wahlstrom, Risto Cukalevski, Jens Danielsson, Jueri Jarvet, Hideki Onagi, et al.
(2012) Biochemistry, 51 p.4280-4289
Journal article

Polystyrene nanoparticles affecting blood coagulation.

Cecilia Oslakovic, Tommy Cedervall, Sara Linse, Björn Dahlbäck
(2012) Nanomedicine: Nanotechnology, Biology and Medicine, 8 p.981-986
Journal article

The fate of aerosol AuNP upon deposition into physiological fluids – Protein corona and aggregation in solution

Christian Svensson, Maria Messing, Martin Lundqvist, Alexander Schollin, Knut Deppert, et al.
(2012)
Poster

Protein interactions with the surface of gold nanoparticles: possible means of determining particle toxicity

Maria Messing, Christian Svensson, A Schollin, Knut Deppert, BO. Meuller, et al.
(2012) Proceedings of the Symposium on Surface Science 2012
Conference paper: abstract

Interactions in the native state of monellin, which play a protective role against aggregation.

Olga Szczepankiewicz, Celia Cabaleiro-Lago, Gian Gaetano Tartaglia, Michele Vendruscolo, Thérèse Hunter, et al.
(2011) Molecular BioSystems, 7 p.521-532
Journal article

Molecular Determinants of S100B Oligomer Formation.

Eva Thulin, Tönu Kesvatera, Sara Linse
(2011) PLoS ONE, 6
Journal article

Aerosol Model Nanoparticles for Protein/Biomolecule Corona Determination in Physiological Buffers - Possible Means of Determining Particle Toxicity and Fate in Humans

Christian Svensson, Maria Messing, A Schollin, Knut Deppert, Bengt Meuller, et al.
(2011) Arbete och hälsa, 45 p.84-85
Conference paper: abstract

Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion.

Mikael Bauer, David J O'Connell, Magdalena Maj, Ludwig Wagner, Dolores J Cahill, et al.
(2011) Molecular BioSystems, 7 p.2196-2204
Journal article

Protein networks involved in vesicle fusion, transport, and storage revealed by array-based proteomics.

Mikael Bauer, Magdalena Maj, Ludwig Wagner, Dolores J Cahill, Sara Linse, et al.
(2011) Methods in Molecular Biology, 781 p.47-58
Journal article

Structural Changes in Apolipoproteins Bound to Nanoparticles

Risto Cukalevski, Martin Lundqvist, Cecilia Oslakovic, Björn Dahlbäck, Sara Linse, et al.
(2011) Langmuir, 27 p.14360-14369
Journal article

Membrane Interaction of α-Synuclein in Different Aggregation States

Marie Grey, Sara Linse, Hanna Nilsson, Patrik Brundin, Emma Sparr
(2011) Journal of Parkinson's Disease, 1 p.359-371
Journal article

The Structural Role of N-Linked Glycans on Human Glypican-1

Gabriel Svensson Birkedal, Axel Hyrenius Wittsten, Sara Linse, Katrin Mani
(2011) Biochemistry, 50 p.9377-9387
Journal article

Aerosol deposition of AuNP into biological fluids produce specific biomolecule corona

Christian Svensson, Maria Messing, Alexander Schollin, Knut Deppert, Bengt Meuller, et al.
(2011) , p.1-2
Conference paper: abstract

Monte Carlo simulations of protein amyloid formation reveal origin of sigmoidal aggregation kinetics.

Björn Linse, Sara Linse
(2011) Molecular BioSystems, 7 p.2296-2303
Journal article

Direct deposition of aerosol generated AuNPs into biological buffers produce specific protein corona in lung-fluid and blood serum

Christian Svensson, Maria Messing, A Schollin, Knut Deppert, Bengt Meuller, et al.
(2011)
Conference paper

Generation, characterisation and deposition of spherical and agglomerated model metal particles for protein corona and toxicological studies.

Christian Svensson, Jenny Rissler, Maria Messing, Knut Deppert, Tommy Cedervall, et al.
(2011) , p.1-1
Conference paper: abstract

Rapid and facile purification of apolipoprotein A-I from human plasma using thermoresponsive nanoparticles

Martin Lundqvist, Tord Berggård, Erik Hellstrand, Iseult Lynch, Kenneth A Dawson, et al.
(2011) Journal of Biomaterials and Nanobiotechnology, 2 p.258-266
Journal article

Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy

Daniele Dell'Orco, Petra Behnen, Sara Linse, Karl-Wilhelm Koch
(2010) Cellular and Molecular Life Sciences, 67 p.973-984
Journal article

Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

Erik Hellstrand, Barry Boland, Dominic M. Walsh, Sara Linse
(2010) ACS Chemical Neuroscience, 1 p.13-18
Journal article

Modeling the Time Evolution of the Nanoparticle-Protein Corona in a Body Fluid

Daniele Dell'Orco, Martin Lundqvist, Cecilia Oslakovic, Tommy Cedervall, Sara Linse
(2010) PLoS ONE, 5
Journal article

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid beta Protein Fibrillation

Celia Cabaleiro-Lago, Fiona Quinlan-Pluck, Iseult Lynch, Kenneth A. Dawson, Sara Linse
(2010) ACS Chemical Neuroscience, 1 p.279-287
Journal article

In vivo protein stabilization based on fragment complementation and a split GFP system.

Stina Lindman, Armando Hernández Garcia, Olga Szczepankiewicz, Birgitta Frohm, Sara Linse
(2010) Proceedings of the National Academy of Sciences, 107 p.19826-19831
Journal article

Integrated protein array screening and high throughput validation of 70 novel neural calmodulin binding proteins

David O'Connell, Mikael Bauer, John O'Brien, Winifred M Johnson, Catherine A Divizio, et al.
(2010) Molecular & Cellular Proteomics, 9 p.1118-1132
Journal article

pK(a) Values for the Unfolded State under Native Conditions Explain the pH-Dependent Stability of PGB1.

Stina Lindman, Mikael Bauer, Mikael Lund, Carl Diehl, Frans Mulder, et al.
(2010) Biophysical Journal, 99 p.3365-3373
Journal article

Retardation of Abeta fibril formation by phospholipid vesicles depends on membrane phase behavior.

Erik Hellstrand, Emma Sparr, Sara Linse
(2010) Biophysical Journal, 98 p.2206-2214
Journal article

Inhibition of IAPP and IAPP((20-29)) Fibrillation by Polymeric Nanoparticles

C. Cabaleiro-Lago, I. Lynch, K. A. Dawson, Sara Linse
(2010) Langmuir, 26 p.3453-3461
Journal article

Role of protein surface charge in monellin sweetness.

Wei-Feng Xue, Olga Szczepankiewicz, Eva Thulin, Sara Linse, Jannette Carey
(2009) Biochimica et Biophysica Acta - Proteins and Proteomics, 1794 p.410-420
Journal article

Towards physico-chemical understanding of fibril formation of the Alzheimer disease-associated amyloid beta-peptide

Sara Linse, Eva Thulin, Erik Hellstrand, Emma Sparr, D. Walsh
(2009) The FEBS Journal, 276 p.11-11
Conference paper: abstract

Protein GB1 Folding and Assembly from Structural Elements.

Mikael Bauer, Wei-Feng Xue, Sara Linse
(2009) International Journal of Molecular Sciences, 10 p.1552-1566
Journal article

A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide

Dominic M. Walsh, Eva Thulin, Aedin M. Minogue, Niklas Gustavsson, Eric Pang, et al.
(2009) The FEBS Journal, 276 p.1266-1281
Journal article

Chemical and Thermal Unfolding of Glypican-1: Protective Effect of Heparan Sulfate against Heat-Induced Irreversible Aggregation

Gabriel Svensson Birkedal, Sara Linse, Katrin Mani
(2009) Biochemistry, 48 p.9994-10004
Journal article

Complete high-density lipoproteins in nanoparticle corona.

Erik Hellstrand, Iseult Lynch, Astra Andersson, Torbjörn Drakenberg, Björn Dahlbäck, et al.
(2009) The FEBS Journal, 276 p.3372-3381
Journal article

Green fluorescence induced by EF-hand assembly in a split GFP system.

Stina Lindman, Ida Johansson, Eva Thulin, Sara Linse
(2009) Protein Science, 18 p.1221-1229
Journal article

Molecular design of specific metal-binding peptide sequences from protein fragments: Theory and experiment

Milan Kozisek, Ales Svatos, Milos Budesinsky, Alexander Muck, Mikael Bauer, et al.
(2008) Chemistry: A European Journal, 14 p.7836-7846
Journal article

BIOL 52-Calmodulin: Site specific chromophore labeling to monitor conformational transitions

Karin Akerfeldt, Sara Linse, Stephanie Kukora, Eva Thulin, Sarah Steenbergen, et al.
(2008) Abstracts of Papers of the American Chemical Society, 236
Conference paper: abstract

Inhibition of Amyloid beta Protein Fibrillation by Polymeric Nanoparticles

Celia Cabaleiro-Lago, Fiona Quinlan-Pluck, Iseult Lynch, Stina Lindman, Aedin M. Minogue, et al.
(2008) Journal of the American Chemical Society, 130 p.15437-15443
Journal article

Zn2+ binding to human calbindin D(28k) and the role of histidine residues.

Mikael Bauer, Hanna Nilsson, Eva Thulin, Birgitta Frohm, Johan Malm, et al.
(2008) Protein Science, 17 p.760-767
Journal article

Calmodulin Binding to the Polybasic C-Termini of STIM Proteins Involved in Store-Operated Calcium Entry.

Mikael Bauer, David O'Connell, Dolores Cahill, Sara Linse
(2008) Biochemistry, 47 p.6089-6091
Journal article

Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex.

Ellen Wang, Mikael Bauer, Annika Rogstam, Sara Linse, Derek Logan, et al.
(2008) Molecular Microbiology, 69 p.466-478
Journal article

Effects of Metal-Binding Loop Mutations on Ligand Binding to Calcium- and Integrin-Binding Protein 1. Evolution of the EF-Hand?

Aaron Yamniuk, Jessica Gifford, Sara Linse, Hans Vogel
(2008) Biochemistry, 47 p.1696-1707
Journal article

Protein folding through kinetic discrimination

Sara Linse, Bjorn Linse
(2007) Journal of the American Chemical Society, 129 p.8481-8486
Journal article

Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity

Stina Lindman, Iseult Lynch, Eva Thulin, Hanna Nilsson, Kenneth Dawson, et al.
(2007) Nano Letters, 7 p.914-920
Journal article

Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles

Tommy Cedervall, Iseult Lynch, Stina Lindman, Tord Berggård, Eva Thulin, et al.
(2007) Proceedings of the National Academy of Sciences, 104 p.2050-2055
Journal article

Protein reconstitution and three-dimensional domain swapping: Benefits and constraints of covalency

Jannette Carey, Stina Lindman, Mikael Bauer, Sara Linse
(2007) Protein Science, 16 p.2317-2333
Journal article review

Detailed identification of plasma proteins adsorbed on copolymer nanoparticles

Tommy Cedervall, Iseult Lynch, Martina Foy, Tord Berggård, Seamas C. Donnelly, et al.
(2007) Angewandte Chemie (International edition), 46 p.5754-5756
Journal article

Binding of calcium ions and SNAP-25 to the hexa EF-hand protein secretagogin

Annika Rogstam, Sara Linse, Anders Lindqvist, Peter James, Ludwig Wagner, et al.
(2007) Biochemical Journal, 401 p.353-363
Journal article

The nanoparticle - protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century

Iseult Lynch, Tommy Cedervall, Martin Lundqvist, Celia Cabaleiro-Lago, Sara Linse, et al.
(2007) Advances in Colloid and Interface Science, 134-135 p.167-174
Journal article

Production and physicochemical characterization of acidocin D20079, a bacteriocin produced by Lactobacillus acidophilus DSM 20079

Sahar Deraz, Martin Hedström, Eva Nordberg Karlsson, Sara Linse, Ashraf A. Khalil, et al.
(2007) World Journal of Microbiology & Biotechnology, 23 p.911-921
Journal article

Residue-specific pK(a) determination of lysine and arginine side chains by indirect N-15 and C-13 NMR spectroscopy: Application to apo calmodulin

Ingemar André, Sara Linse, Frans Mulder
(2007) Journal of the American Chemical Society, 129 p.15805-15813
Journal article

Structural properties of semenogelin I.

Johan Malm, Magnus Jonsson, Birgitta Frohm, Sara Linse
(2007) The FEBS Journal, 274 p.4503-4510
Journal article

Nucleation of protein fibrillation by nanoparticles

Sara Linse, Celia Cabaleiro-Lago, Wei-Feng Xue, Iseult Lynch, Stina Lindman, et al.
(2007) Proceedings of the National Academy of Sciences, 104 p.8691-8696
Journal article

Methods for the detection and analysis of protein-protein interactions

Tord Berggård, Sara Linse, Peter James
(2007) Proteomics, 7 p.2833-2842
Journal article review

pK(a) values for side-chain carboxyl groups of a PGB1 variant explain salt and pH-dependent stability

Stina Lindman, Sara Linse, Frans Mulder, Ingemar André
(2007) Biophysical Journal, 92 p.257-266
Journal article

Intra- versus intermolecular interactions in monellin: Contribution of surface charges to protein assembly

Wei-Feng Xue, Olga Szczepankiewicz, Mikael Bauer, Eva Thulin, Sara Linse
(2006) Journal of Molecular Biology, 358 p.1244-1255
Journal article

Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein.

Jenny J Persson, Bernard Beall, Sara Linse, Gunnar Lindahl
(2006) PLoS Pathogens, 2 p.442-452
Journal article

Reconstitution of calmodulin from domains and subdomains: Influence of target peptide

Cynthia Shuman, R Jiji, K S Akerfeldt, Sara Linse
(2006) Journal of Molecular Biology, 358 p.870-881
Journal article

Truncated semenogelin I binds zinc and is cleaved by prostate-specific antigen

Magnus Jonsson, Åke Lundwall, Sara Linse, Birgitta Frohm, Johan Malm
(2006) Journal of Andrology, 27 p.542-547
Journal article

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

Tord Berggård, Giorgio Arrigoni, Olof Olsson, Malin Fex, Sara Linse, et al.
(2006) Journal of Proteome Research, 5 p.669-687
Journal article

Streptococcal M protein: Structural studies of the hypervariable region, free and bound to human C4BP

Ingemar André, J Persson, AM Blom, H Nilsson, Torbjörn Drakenberg, et al.
(2006) Biochemistry, 45 p.4559-4568
Journal article

Binding of calcium to anticoagulant protein S: role of the fourth EGF module.

Kristina Persson, Johan Stenflo, Sara Linse, Yvonne Stenberg, Roger J S Preston, et al.
(2006) Biochemistry, 45 p.10682-10689
Journal article

Electrostatic contributions to residue-specific protonation equilibria and proton binding capacitance for a small protein

Stina Lindman, Sara Linse, Frans Mulder, Ingemar André
(2006) Biochemistry, 45 p.13993-14002
Journal article

Salting the charged surface: pH and salt dependence of protein G B1 stability

Stina Lindman, Wei-Feng Xue, Olga Szczepankiewicz, Mikael Bauer, Hanna Nilsson, et al.
(2006) Biophysical Journal, 90 p.2911-2921
Journal article

Salt enhances calmodulin-target interaction

Ingemar André, Tönu Kesvatera, Bo Jönsson, Sara Linse
(2006) Biophysical Journal, 90 p.2903-2910
Journal article

Stability of HAMLET--A kinetically trapped {alpha}-lactalbumin oleic acid complex.

Jonas Fast, Anki Mossberg, Catharina Svanborg, Sara Linse
(2005) Protein Science, 14 p.329-340
Journal article

Calbindin D-28k EF-hand ligand binding and oligomerization: Four high-affinity sites-three modes of action

Tommy Cedervall, Ingemar André, C Selah, J P Robblee, P C Krecioch, et al.
(2005) Biochemistry, 44 p.13522-13532
Journal article

Redox sensitive cysteine residues in calbindin D(28)k are structurally and functionally important

Tommy Cedervall, Tord Berggård, V Borek, Eva Thulin, Sara Linse, et al.
(2005) Biochemistry, 44 p.684-693
Journal article

Binding of charged ligands to macromolecules. Anomalous salt dependence

Fernando Luis B da Silva, Sara Linse, Bo Jönsson
(2005) The Journal of Physical Chemistry Part B, 109 p.2007-2013
Journal article

Compact oleic acid in HAMLET.

Jonas Fast, Anki Mossberg, Hanna Nilsson, Catharina Svanborg, Mikael Akke, et al.
(2005) FEBS Letters, 579 p.6095-6100
Journal article

Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen

Magnus Jonsson, Sara Linse, Birgitta Frohm, Åke Lundwall, Johan Malm
(2005) Biochemical Journal, 387 p.447-453
Journal article

Deamidation and disulfide bridge formation in human calbindin D-2gk with effects on calcium binding

Christophe Vanbelle, F Halgand, Tommy Cedervall, Eva Thulin, K S Akerfeldt, et al.
(2005) Protein Science, 14 p.968-979
Journal article

Electrostatic contributions to the kinetics and thermodynamics of protein assembly

D Dell'Orco, Wei-Feng Xue, Eva Thulin, Sara Linse
(2005) Biophysical Journal, 88 p.1991-2002
Journal article

Characterization of calretinin I-II as an EF-hand, Ca2+, H+-sensing domain

M Palczewska, G Batta, P Groves, Sara Linse, J Kuznicki
(2005) Protein Science, 14 p.1879-1887
Journal article

Multi-method global analysis of thermodynamics and kinetics in reconstitution of monellin

Wei-Feng Xue, J Carey, Sara Linse
(2004) Proteins, 57 p.586-595
Journal article

Letter to the Editor: Sequential H-1, N-15 and C-13 NMR assignment of human calbindin D28k

Magnus Helgstrand, Christophe Vanbelle, Eva Thulin, Sara Linse, Mikael Akke
(2004) Journal of Biomolecular NMR, 28 p.305-306
Journal article

The role of electrostatic interactions in calmodulin-peptide complex formation

Ingemar André, Tönu Kesvatera, Bo Jönsson, KS Akerfeldt, Sara Linse
(2004) Biophysical Journal, 87 p.1929-1938
Journal article

alpha-Lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Malin Svensson, Jonas Fast, Anki Mossberg, Caroline Düringer, Lotta Gustafsson, et al.
(2003) Protein Science, 12 p.2794-2804
Journal article

The modular organisation and stability of a thermostable family 10 xylanase

Maher Abou-Hachem, Fredrik Olsson, M P Williamson, Sara Linse, S J Crennell, et al.
(2003) Biocatalysis and Biotransformation, 21 p.253-260
Journal article

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.

Catharina Svanborg, Helena Ågerstam, Annika Aronson, Rolf Bjerkvig, Caroline Düringer, et al.
(2003) Advances in Cancer Research, 88 p.1-29
Journal article review

Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Malin Svensson, Anki Mossberg, Jenny Pettersson, Sara Linse, Catharina Svanborg
(2003) Protein Science, 12 p.2805-2814
Journal article

Structural requirements of anticoagulant protein S for its binding to the complement regulator c4b-binding protein

TK Giri, Sara Linse, Pablo Garcia de Frutos, Tomio Yamazaki, BO Villoutreix, et al.
(2002) Journal of Biological Chemistry, 277 p.15099-15106
Journal article

Measurement of Ca2+-binding constants of proteins and presentation of the CaLigator software.

Ingemar André, Sara Linse
(2002) Analytical Biochemistry, 305 p.195-205
Journal article

Protein reconstitution and 3D domain swapping.

Maria Håkansson, Sara Linse
(2002) Current Protein and Peptide Science, 3 p.629-642
Journal article review

myo-Inositol monophosphatase is an activated target of calbindin D28k.

Tord Berggård, Olga Szczepankiewicz, Eva Thulin, Sara Linse
(2002) Journal of Biological Chemistry, 277 p.41954-41959
Journal article

A Proline-Rich Region with a Highly Periodic Sequence in Streptococcal beta Protein Adopts the Polyproline II Structure and Is Exposed on the Bacterial Surface.

Thomas Areschoug, Sara Linse, Margaretha Stålhammar-Carlemalm, Lars-Olof Hedén, Gunnar Lindahl
(2002) Journal of Bacteriology, 184 p.6376-6383
Journal article

Calcium binding to proteins studied via competition with chromophoric chelators.

Sara Linse
(2002) Methods in Molecular Biology, 173 p.15-24
Journal article

Isolation and detection of human IgA using a streptococcal IgA-binding peptide.

Charlotta Sandin, Sara Linse, Thomas Areschoug, Jenny M Woof, Jesper Reinholdt, et al.
(2002) Journal of Immunology, 169 p.1357-1364
Journal article

Coupling of ligand binding and dimerization of helix-loop-helix peptides: Spectroscopic and sedimentation analyses of calbindin D-9k EF-hands

Karin Julenius, James Robblee, Eva Thulin, Bryan E Finn, Robert Fairman, et al.
(2002) Proteins, 47 p.323-333
Journal article

Calcium binding and thermostability of carbohydrate binding module CBM4-2 of Xyn10A from Rhodothermus marinus.

Maher Abou-Hachem, Eva Nordberg Karlsson, Peter J Simpson, Sara Linse, Peter Sellers, et al.
(2002) Biochemistry, 41 p.5720-5729
Journal article

Calbindin D28k exhibits properties characteristic of a Ca2+ sensor.

Tord Berggård, Simona Miron, Patrik Önnerfjord, Eva Thulin, Karin S Akerfeldt, et al.
(2002) Journal of Biological Chemistry, 277 p.16662-16672
Journal article

Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells

Malin Svensson, Caroline Düringer, Oskar Hallgren, Anki Mossberg, Anders P Håkansson, et al.
(2002) Advances in Experimental Medicine and Biology, 503 p.32-125
Journal article

Isolated hypervariable regions derived from streptococcal M proteins specifically bind human C4b-binding protein: Implications for antigenic variation

Eva Morfeldt, Karin Berggård, Jenny Persson, Torbjörn Drakenberg, Eskil Johnsson, et al.
(2001) Journal of Immunology, 167 p.3870-3877
Journal article

The chaperone-like activity of a small heat shock protein is lost after sulfoxidation of conserved methionines in a surface-exposed amphipathic α-helix

Ulrika Härndahl, Bas P.A. Kokke, Niklas Gustavsson, Sara Linse, Kristina Berggren, et al.
(2001) BBA - Protein Structure and Molecular Enzymology, 1545 p.227-237
Journal article

Sara Linse

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