The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Portrait of Sara Snogerup Linse

Sara Linse


Portrait of Sara Snogerup Linse

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter


  • Roxine Staats
  • Thomas C.T. Michaels
  • Patrick Flagmeier
  • Sean Chia
  • Robert I. Horne
  • Johnny Habchi
  • Sara Linse
  • Tuomas P.J. Knowles
  • Christopher M. Dobson
  • Michele Vendruscolo

Summary, in English

The aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modifying treatments, there is an unmet need of developing novel methods of drug discovery. In this context, the use of chemical kinetics has recently enabled accurate quantifications of the microscopic steps leading to the proliferation of protein misfolded oligomers. As these species are highly neurotoxic, effective therapeutic strategies may be aimed at reducing their numbers. Here, we exploit this quantitative approach to develop a screening strategy that uses the reactive flux toward α-synuclein oligomers as a selection parameter. Using this approach, we evaluate the efficacy of a library of flavone derivatives, identifying apigenin as a compound that simultaneously delays and reduces the formation of α-synuclein oligomers. These results demonstrate a compound selection strategy based on the inhibition of the formation of α-synuclein oligomers, which may be key in identifying small molecules in drug discovery pipelines for diseases associated with α-synuclein aggregation.


  • Biochemistry and Structural Biology
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • NanoLund: Center for Nanoscience

Publishing year





Communications Chemistry





Document type

Journal article


Springer Nature


  • Neurosciences
  • Biochemistry and Molecular Biology




  • ISSN: 2399-3669