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Portrait of Sara Snogerup Linse

Sara Linse


Portrait of Sara Snogerup Linse

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes


  • Ryan Limbocker
  • Sean Chia
  • Francesco S. Ruggeri
  • Michele Perni
  • Roberta Cascella
  • Gabriella T. Heller
  • Georg Meisl
  • Benedetta Mannini
  • Johnny Habchi
  • Thomas C.T. Michaels
  • Pavan K. Challa
  • Minkoo Ahn
  • Samuel T. Casford
  • Nilumi Fernando
  • Catherine K. Xu
  • Nina D. Kloss
  • Samuel I.A. Cohen
  • Janet R. Kumita
  • Cristina Cecchi
  • Michael Zasloff
  • Sara Linse
  • Tuomas P.J. Knowles
  • Fabrizio Chiti
  • Michele Vendruscolo
  • Christopher M. Dobson

Summary, in English

Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ42) are key pathogenic agents in Alzheimer’s disease (AD). To investigate the relationship between Aβ42 aggregation and its cytotoxicity and the influence of a potential drug on both phenomena, we have studied the effects of trodusquemine. This aminosterol enhances the rate of aggregation by promoting monomer-dependent secondary nucleation, but significantly reduces the toxicity of the resulting oligomers to neuroblastoma cells by inhibiting their binding to the cellular membranes. When administered to a C. elegans model of AD, we again observe an increase in aggregate formation alongside the suppression of Aβ42-induced toxicity. In addition to oligomer displacement, the reduced toxicity could also point towards an increased rate of conversion of oligomers to less toxic fibrils. The ability of a small molecule to reduce the toxicity of oligomeric species represents a potential therapeutic strategy against AD.


  • Biochemistry and Structural Biology
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • NanoLund: Center for Nanoscience

Publishing year





Nature Communications





Document type

Journal article


Nature Publishing Group


  • Medicinal Chemistry
  • Cell and Molecular Biology




  • ISSN: 2041-1723