The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Portrait of Tommy Cedervall; Photo: Kennet Ruona

Tommy Cedervall

Associate Professor, Coordinator Nanosafety

Portrait of Tommy Cedervall; Photo: Kennet Ruona

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid


  • Rebecca Frankel
  • Mattias Törnquist
  • Georg Meisl
  • Oskar Hansson
  • Ulf Andreasson
  • Henrik Zetterberg
  • Kaj Blennow
  • Birgitta Frohm
  • Tommy Cedervall
  • Tuomas P.J. Knowles
  • Thom Leiding
  • Sara Linse

Summary, in English

Alzheimer’s disease is linked to amyloid β (Aβ) peptide aggregation in the brain, and a detailed understanding of the molecular mechanism of Aβ aggregation may lead to improved diagnostics and therapeutics. While previous studies have been performed in pure buffer, we approach the mechanism in vivo using cerebrospinal fluid (CSF). We investigated the aggregation mechanism of Aβ42 in human CSF through kinetic experiments at several Aβ42 monomer concentrations (0.8–10 µM). The data were subjected to global kinetic analysis and found consistent with an aggregation mechanism involving secondary nucleation of monomers on the fibril surface. A mechanism only including primary nucleation was ruled out. We find that the aggregation process is composed of the same microscopic steps in CSF as in pure buffer, but the rate constant of secondary nucleation is decreased. Most importantly, the autocatalytic amplification of aggregate number through catalysis on the fibril surface is prevalent also in CSF.


  • Physical Chemistry
  • NanoLund: Center for Nanoscience
  • Biochemistry and Structural Biology
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Clinical Memory Research

Publishing year





Communications Biology





Document type

Journal article


Nature Publishing Group


  • Neurosciences



Research group

  • Clinical Memory Research


  • ISSN: 2399-3642