The overall objective is to increase our understanding of the fundamental connections between particle properties and human and environmental toxicology, as well as of emissions and exposure in all stages of the lifecycle of a nanomaterial. The research aims at providing the tools needed to implement Safe(r)-by-design in the development and production of novel materials.
Emissions and exposure
To generate the knowledge needed to implement Safe(r)-by-design, we assess “real world” emissions and exposure in all stages of the life cycle of a nanomaterial as well as properties of emitted particles using state-of-the-art on-line and off-line methods.
Effects on cellular, organism and ecosystem level
To understand the fundamental connections between particle properties and human and environmental toxicology we study toxicological effects on all levels, from single cells to ecosystems using various in-vitro, ex-vivo, and in-vivo methods. We also study trophic transfer of nanomaterials, as well as the toxic effects thereof, using model ecosystems and mesocosm systems.
Risk assessment and risk management
Safe production and use of nanomaterials requires effective risk management. For this purpose, we combine nano-related exposure and toxicity knowledge with state-of-the-art processes and procedures for risk management, ranging from legislative and regulative levels down to hands-on work processes.