Apr
NanoBio – microworkshop: Biophysics of Bone and Enamel, Hanna Isaksson and Johan Svensson Bonde
For this week's NanoBio micro workshop, the topic is Biophysics of Bone and Enamel, Hanna Isaksson and Johan Svensson Bonde
28 APR in room H421 – Biophysics of Bone and Enamel, Hanna Isaksson and Johan Svensson Bonde
. https://portal.research.lu.se/sv/persons/hanna-isaksson
. https://portal.research.lu.se/sv/persons/johan-svensson-bonde
Fairly short presentations are combined with intense open-minded discussions. Make sure to prepare some questions in advance!
Nanostructures in Enamel Formation and Engineering of the Enamel Matrix Protein Amelogenin
Johan Bonde, Division of Pure and Applied Biochemistry
Dental enamel is formed during early tooth development and is the hardest mammalian tissue. During its lifetime enamel gets exposed to substantial mechanical, chemical and microbial stress, without the possibility to heal itself, and thus needs to be made to last. Enamel is composed of highly elongated hydroxyapatite (HAP) nanocrystals, organized in bundles that provide a close to woven architecture. The nanostructure of enamel is established early during enamel formation by proteins in the extracellular enamel matrix. The EM is dominated by the protein amelogenin (AMG) that comprise >90% of the organic part of the matrix. AMG can self-assemble into several distinct nanostructures including 30 nm nanospheres and 15 nm wide nanoribbons. Recently, AMG nanoribbons have been demonstrated to be functional amyloids (non-pathogenic) able to template HAP nanocrystal morphology and organization, suggesting a key role in enamel formation.
In our research we work with understanding the role AMG nanoribbons in biological enamel formation, and with exploring AMG as a platform for protein-based materials. For this we use genetic engineering to produce native and engineered AMG that can be assembled in vitro into protein-based nanostructures. These different aspects will be covered in the presentation.
Multiscale and multimodal assessment of bone damage in aging bone
Hanna Isaksson, Division of Biomedical Engineering
Bone is a fascinating tissue. Its hierarchically optimized structure and unique composition result in a strong and tough material. However, when affected by degenerative diseases, its strength and fracture resistance can diminish substantially. The quality of bone and its fracture resistance are related to a combination of factors, including its structure, composition and function. Thus, understanding how bone fails and fractures as an organ requires an investigation of its mechanical behavior on different length scales - all the way down to the nanoscale. This presentation will discuss our combined effort to understand bone strength, its damage- and toughening mechanisms on multiple length scales going from macro- to micro- to nanoscale, using experimental in situ mechanical testing as ground for development and validation of numerical modeling strategies of strength, damage, and fracture, and how these aspects are affected by aging.
Welcome!
Jonas & Oxana
coordinators NanoBio / NanoLund
https://www.nano.lu.se/research/life-science-nano
Future micro workshops scheduled for the spring:
16 JUNE in room K404 – Ethics and Philosophy in Medicine, Mats Johansson
. https://portal.research.lu.se/sv/persons/mats-johansson
About the event
Location:
H421, Fysicum
Contact:
jonas [dot] tegenfeldt [at] ftf [dot] lth [dot] se